Malignant mesothelioma of the tunica vaginalis testis in a petrochemical worker exposed to asbestos

Stefano M. Candura, Andrea Canto, Alessio Amatu, Matteo Gerardini, Giorgio Stella, Mario Mensi, Guido Poggi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Malignant mesothelioma of the tunica vaginalis testis is a rare and aggressive asbestos-related malignancy that may pose difficult diagnostic problems. After 16 years of asbestos exposure, a 38-year-old petrochemical worker came to our notice with acute right testicular pain and swelling, simulating torsion of the spermatic cord. Histopathology of surgical samples of the tunica vaginalis revealed tubulopapillary, epithelioid neoplastic proliferation. Immunohistochemical staining for the epithelial glycoprotein Ber-EP4 was negative, whereas results were positive for mesothelial markers, thus leading to the diagnosis of epithelial mesothelioma. The tumour infiltrated the testicular surface and the epididymis, but no distant metastases were found. The patient was treated with radical inguinal orchidectomy without adjuvant therapy and is free from disease 15 months after diagnosis. Tunical mesothelioma may simulate metastatic carcinoma at routine histopathological examination. Immunohistochemistry and occupational anamnesis are helpful for the correct diagnosis, which, in turn, is important for prognosis and treatment, and in relation to legal issues when asbestos is involved in the causation of the disease.

Original languageEnglish
Pages (from-to)1365-1368
Number of pages4
JournalAnticancer Research
Volume28
Issue number2 B
Publication statusPublished - Mar 2008

Fingerprint

Asbestos
Testis
Mesothelioma
Spermatic Cord Torsion
Orchiectomy
Groin
Epididymis
Testicular Neoplasms
Causality
Glycoproteins
Immunohistochemistry
Staining and Labeling
Neoplasm Metastasis
Carcinoma
Pain
Therapeutics
Malignant Mesothelioma
Neoplasms

Keywords

  • Asbestos
  • Calretinin
  • Immunohistochemistry
  • Mesothelioma
  • Occupational cancer
  • Orchidectomy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Candura, S. M., Canto, A., Amatu, A., Gerardini, M., Stella, G., Mensi, M., & Poggi, G. (2008). Malignant mesothelioma of the tunica vaginalis testis in a petrochemical worker exposed to asbestos. Anticancer Research, 28(2 B), 1365-1368.

Malignant mesothelioma of the tunica vaginalis testis in a petrochemical worker exposed to asbestos. / Candura, Stefano M.; Canto, Andrea; Amatu, Alessio; Gerardini, Matteo; Stella, Giorgio; Mensi, Mario; Poggi, Guido.

In: Anticancer Research, Vol. 28, No. 2 B, 03.2008, p. 1365-1368.

Research output: Contribution to journalArticle

Candura, SM, Canto, A, Amatu, A, Gerardini, M, Stella, G, Mensi, M & Poggi, G 2008, 'Malignant mesothelioma of the tunica vaginalis testis in a petrochemical worker exposed to asbestos', Anticancer Research, vol. 28, no. 2 B, pp. 1365-1368.
Candura SM, Canto A, Amatu A, Gerardini M, Stella G, Mensi M et al. Malignant mesothelioma of the tunica vaginalis testis in a petrochemical worker exposed to asbestos. Anticancer Research. 2008 Mar;28(2 B):1365-1368.
Candura, Stefano M. ; Canto, Andrea ; Amatu, Alessio ; Gerardini, Matteo ; Stella, Giorgio ; Mensi, Mario ; Poggi, Guido. / Malignant mesothelioma of the tunica vaginalis testis in a petrochemical worker exposed to asbestos. In: Anticancer Research. 2008 ; Vol. 28, No. 2 B. pp. 1365-1368.
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