Between 1951 and 1976 100 patients with extranodal malignant non-Hodgkin's lymphoma (NHL) in the head and neck area (78 patients) or of the gastrointestinal tract (22 patients) were treated by radiotherapy. In 85 of these patients the histological sections could be classified according to Rappaport. 79 showed a diffuse pattern and the most frequent diagnosis (40%) was diffuse lymphocytic poorly differentiated (DLPD). Upon histologic reevaluation, 49 of 63 head and neck patients and 13 patients with gastrointestinal tract tumors were classified as stage IE or IIE. Only 13 of these 62 patients, all in the head and neck group, had pretreatment pathological staging (PS). 56% (10/18) of the head and neck patients and 100% (6/6) of the gastrointestinal tract cases in stage IE survived disease free for over 5 years. Eleven of 13 head and neck patients in stage IE or IIE after staging have been followed for over 4 years. 55% (6/11) have remained disease free. Lymph node involvement indicates primary generalized disease in a large percentage of such cases. This is demonstrated by the low disease free survival rate of 9% (2/23) for head and neck patients in stage IIE treated by radiotherapy alone without pretreatment staging (clinical stage). Problems regarding the indications for and techniques of radiotherapy of the head and neck region and the gastrointestinal tract are discussed. Extended field radiotherapy excluding the mediastinum is recommended for extranodal NHL of the head and neck region. Total abdominal irradiation is indicated for extranodal NHL limited to the abdomen. Only 7% (4/62) of the patients had a true local relapse following radiotherapy. 10% (8/85) of the patients relapsed in the head and neck region or gastrointestinal tract. These special observations of extranodal NHL do not indicate any particular relationship between the head and neck region and the gastrointestinal tract, but are explained by the relative frequency of extranodal NHL in these areas.
|Translated title of the contribution||Malignant non-Hodgkin's lymphoma in the head and neck area and the gastrointestinal tract. Results, indication and technique of radiotherapy|
|Number of pages||8|
|Journal||Schweizerische Medizinische Wochenschrift|
|Publication status||Published - 1980|
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