Malignant pleural mesothelioma: Multivariate analysis of prognostic factors on 113 patients

V. Fusco; A. Ardizzoni; F. Merlo; A. Cinquegrana; B. Faravelli; M. De Palma; L. Chessa; G. Nicolo; M. Serra; A. Capaccio; R. Rosso

Malignant pleural mesothelioma: Multivariate analysis of prognostic factors on 113 patients

V. Fusco, A. Ardizzoni, F. Merlo, A. Cinquegrana, B. Faravelli, M. De Palma, L. Chessa, G. Nicolo, M. Serra, A. Capaccio, R. Rosso

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

We report on clinical features of 113 cases of pathologically confirmed Malignant Pleural Mesothelioma, observed in Genoa (Italy) between 1979 and 1985. Overall median survival was 10 months. Among the pretreatment variables studied (age, sex, asbestos exposure, pathological type, chest pain and dyspnea et the time of diagnosis), the only one of prognostic value in the univariate analysis was the histological subtype: median survivals were l2, 7 and 4 months for the patients in the epithelial, mixed, and fibrosarcomatous groups, respectively (p = 0.0012). A multivariate analysis confirmed the independent predictive power of the histotype (p = 0.0022). A review of literature data concerning prognostic factors in Malignant Pleural Mesothelioma is presented.

Original language	English
Pages (from-to)	683-689
Number of pages	7
Journal	Anticancer Research
Volume	13
Issue number	3
Publication status	Published - 1993

Keywords

Mesothelioma
Multivariate analysis
Pleural diseases
Prognostic factors

ASJC Scopus subject areas

Cancer Research
Oncology

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title = "Malignant pleural mesothelioma: Multivariate analysis of prognostic factors on 113 patients",

abstract = "We report on clinical features of 113 cases of pathologically confirmed Malignant Pleural Mesothelioma, observed in Genoa (Italy) between 1979 and 1985. Overall median survival was 10 months. Among the pretreatment variables studied (age, sex, asbestos exposure, pathological type, chest pain and dyspnea et the time of diagnosis), the only one of prognostic value in the univariate analysis was the histological subtype: median survivals were l2, 7 and 4 months for the patients in the epithelial, mixed, and fibrosarcomatous groups, respectively (p = 0.0012). A multivariate analysis confirmed the independent predictive power of the histotype (p = 0.0022). A review of literature data concerning prognostic factors in Malignant Pleural Mesothelioma is presented.",

keywords = "Mesothelioma, Multivariate analysis, Pleural diseases, Prognostic factors",

author = "V. Fusco and A. Ardizzoni and F. Merlo and A. Cinquegrana and B. Faravelli and {De Palma}, M. and L. Chessa and G. Nicolo and M. Serra and A. Capaccio and R. Rosso",

year = "1993",

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TY - JOUR

T1 - Malignant pleural mesothelioma

T2 - Multivariate analysis of prognostic factors on 113 patients

AU - Fusco, V.

AU - Ardizzoni, A.

AU - Merlo, F.

AU - Cinquegrana, A.

AU - Faravelli, B.

AU - De Palma, M.

AU - Chessa, L.

AU - Nicolo, G.

AU - Serra, M.

AU - Capaccio, A.

AU - Rosso, R.

PY - 1993

Y1 - 1993

N2 - We report on clinical features of 113 cases of pathologically confirmed Malignant Pleural Mesothelioma, observed in Genoa (Italy) between 1979 and 1985. Overall median survival was 10 months. Among the pretreatment variables studied (age, sex, asbestos exposure, pathological type, chest pain and dyspnea et the time of diagnosis), the only one of prognostic value in the univariate analysis was the histological subtype: median survivals were l2, 7 and 4 months for the patients in the epithelial, mixed, and fibrosarcomatous groups, respectively (p = 0.0012). A multivariate analysis confirmed the independent predictive power of the histotype (p = 0.0022). A review of literature data concerning prognostic factors in Malignant Pleural Mesothelioma is presented.

AB - We report on clinical features of 113 cases of pathologically confirmed Malignant Pleural Mesothelioma, observed in Genoa (Italy) between 1979 and 1985. Overall median survival was 10 months. Among the pretreatment variables studied (age, sex, asbestos exposure, pathological type, chest pain and dyspnea et the time of diagnosis), the only one of prognostic value in the univariate analysis was the histological subtype: median survivals were l2, 7 and 4 months for the patients in the epithelial, mixed, and fibrosarcomatous groups, respectively (p = 0.0012). A multivariate analysis confirmed the independent predictive power of the histotype (p = 0.0022). A review of literature data concerning prognostic factors in Malignant Pleural Mesothelioma is presented.

KW - Mesothelioma

KW - Multivariate analysis

KW - Pleural diseases

KW - Prognostic factors

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