Malignant sarcomatoid mesothelioma of the pleura: a histological and immunohistological study of a case.

C. Avellini, G. Alampi, V. Cocchi, E. Sabattini, R. Agosti, M. Schiavina, S. Pileri, A. Piccaluga

Research output: Contribution to journalArticlepeer-review

Abstract

The authors describe the case of a 70 year-old asymptomatic female, who showed nodular pleural growths at an occasional chest roentgenogram. Histological examinations and laboratory findings excluded the possibility of an inflammatory granulomatous process, but they did not allow differentiation between malignant sarcomatoid pleural mesothelioma and malignant fibrous histiocytoma. Only at immunohistochemistry was the differential diagnosis made. In fact, the co-expression of vimentin and cytokeratins by neoplastic cells, along with their negativity for macrophage markers strongly supported the hypothesis that the neoplastic growth originated from subpleural mesenchymal stem cells.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalPathologica
Volume83
Issue number1085
Publication statusPublished - May 1991

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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