Malignant solitary fibrous tumors in a renal allograft: The nephron-sparing surgery option

Marco Casaccia, Iris Fontana, Ilaria Nardi, Massimo Bertocchi, Davide Ghinolfi, Mark Sturdevant, Raffaella Gentile, Umberto Valente

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Malignant solitary fibrous tumors (SFT) of the kidney are an unusual entity. In a search of the medical literature, this tumor has never been described in a renal allograft. We report a case of a 70-year-old female who developed a bifocal malignant SFT in a renal allograft 12 years after transplantation. The patient underwent enucleation of both lesions. Microscopic evaluation showed neoplastic proliferation of spindle-shaped cells showing moderate atypia and frequent mitotic figures. At 12-month follow-up, the patient was tumor-free and had preserved renal allograft function. Although transplant nephrectomy might be the conventional treatment for this pathology, a nephron-sparing surgical approach allowed for the removal of both tumors while preserving allograft function. In this case, an informed patient dictated a treatment modality that would best maintain her high quality of life coupled with a reasonable expectation of a cure.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalDialysis and Transplantation
Volume39
Issue number4
DOIs
Publication statusPublished - Apr 2010

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Solitary Fibrous Tumors
Nephrons
Allografts
Kidney
Neoplasms
Nephrectomy
Transplantation
Quality of Life
Pathology
Transplants
Therapeutics

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Casaccia, M., Fontana, I., Nardi, I., Bertocchi, M., Ghinolfi, D., Sturdevant, M., ... Valente, U. (2010). Malignant solitary fibrous tumors in a renal allograft: The nephron-sparing surgery option. Dialysis and Transplantation, 39(4), 151-157. https://doi.org/10.1002/dat.20425

Malignant solitary fibrous tumors in a renal allograft : The nephron-sparing surgery option. / Casaccia, Marco; Fontana, Iris; Nardi, Ilaria; Bertocchi, Massimo; Ghinolfi, Davide; Sturdevant, Mark; Gentile, Raffaella; Valente, Umberto.

In: Dialysis and Transplantation, Vol. 39, No. 4, 04.2010, p. 151-157.

Research output: Contribution to journalArticle

Casaccia, M, Fontana, I, Nardi, I, Bertocchi, M, Ghinolfi, D, Sturdevant, M, Gentile, R & Valente, U 2010, 'Malignant solitary fibrous tumors in a renal allograft: The nephron-sparing surgery option', Dialysis and Transplantation, vol. 39, no. 4, pp. 151-157. https://doi.org/10.1002/dat.20425
Casaccia M, Fontana I, Nardi I, Bertocchi M, Ghinolfi D, Sturdevant M et al. Malignant solitary fibrous tumors in a renal allograft: The nephron-sparing surgery option. Dialysis and Transplantation. 2010 Apr;39(4):151-157. https://doi.org/10.1002/dat.20425
Casaccia, Marco ; Fontana, Iris ; Nardi, Ilaria ; Bertocchi, Massimo ; Ghinolfi, Davide ; Sturdevant, Mark ; Gentile, Raffaella ; Valente, Umberto. / Malignant solitary fibrous tumors in a renal allograft : The nephron-sparing surgery option. In: Dialysis and Transplantation. 2010 ; Vol. 39, No. 4. pp. 151-157.
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