Malignant transformation of glucagonoma with SPECT/CT In-111 OctreoScan features

A case report

Giuseppe Corrias, Natally Horvat, Serena Monti, Olca Basturk, Oscar Lin, Luca Saba, Lisa Bodei, Diane L. Reidy, Lorenzo Mannelli

Research output: Contribution to journalArticle

Abstract

Rationale: Glucagonoma is an uncommon disease but it has been associated with a pattern of symptoms defined as glucagonoma syndrome. These symptoms, if promptly recognized, could help to speed up the diagnosing process. Patient concerns: We report a case of a 68-year-old woman with a pancreatic glucagonoma. Her symptoms at the onset were typical of the glucagonoma syndrome. Diagnoses: After a significant weight loss, she underwent a computer tomography scan of the abdomen, which showed a hypervascular lesion of the tail of the pancreas and hypervascular lesions of the liver. An ultrasound guided biopsy was performed and pathology was consistent with glucagonoma. Her blood glucagon levels were elevated. Outcomes: She was treated with chemotherapy and somatostatin analogs. After 4 years, the disease had a malignant transformation, and metastases suddenly started to grow up. She stopped being responsive to treatment and eventually passed away. Lessons: Due to its rarity, clinical diagnosis is challenging and generally it comes after a long interval since the onset of symptoms. Awareness of physicians and dermatologists of the characteristic necrolytic migratory erythema, and of the other symptoms, often leads to early diagnosis.

Original languageEnglish
Article numbere9252
JournalMedicine (United States)
Volume96
Issue number50
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Glucagonoma
Necrolytic Migratory Erythema
Somatostatin
Glucagon
Abdomen
Weight Loss
Early Diagnosis
Pancreas
Tomography
pentetreotide
Single Photon Emission Computed Tomography Computed Tomography
Pathology
Neoplasm Metastasis
Physicians
Biopsy
Drug Therapy
Liver

Keywords

  • Glucagonoma
  • Multidetector computed tomography
  • Neuroendocrine tumors
  • OctreoScan
  • Somatostatin receptor imaging

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Malignant transformation of glucagonoma with SPECT/CT In-111 OctreoScan features : A case report. / Corrias, Giuseppe; Horvat, Natally; Monti, Serena; Basturk, Olca; Lin, Oscar; Saba, Luca; Bodei, Lisa; Reidy, Diane L.; Mannelli, Lorenzo.

In: Medicine (United States), Vol. 96, No. 50, e9252, 01.12.2017.

Research output: Contribution to journalArticle

Corrias, G, Horvat, N, Monti, S, Basturk, O, Lin, O, Saba, L, Bodei, L, Reidy, DL & Mannelli, L 2017, 'Malignant transformation of glucagonoma with SPECT/CT In-111 OctreoScan features: A case report', Medicine (United States), vol. 96, no. 50, e9252. https://doi.org/10.1097/MD.0000000000009252
Corrias, Giuseppe ; Horvat, Natally ; Monti, Serena ; Basturk, Olca ; Lin, Oscar ; Saba, Luca ; Bodei, Lisa ; Reidy, Diane L. ; Mannelli, Lorenzo. / Malignant transformation of glucagonoma with SPECT/CT In-111 OctreoScan features : A case report. In: Medicine (United States). 2017 ; Vol. 96, No. 50.
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