Malondialdheyde production features in platelets of Parkinson and Alzheimer patients and in physiological aging

L. Bet, E. Calabrese, L. Bava, E. Magni, S. Rapuzzi, G. Pezzoli, C. Mariani

Research output: Contribution to journalArticlepeer-review

Abstract

Malondialdheyde (MDA), a marker of free radical-induced lipid peroxidation, was measured in basal condition and after stimulation with a free radical generating system in platelets of Parkinson's (PD) and Alzheimer's (AD) patient and in normal subjects of different ages. Superoxide dismutase (SOD) activity was determined to assess the platelet detoxification capacity. In normal subjects at any age stimulated MDA levels were significantly higher compared with levels of basal MDA and this difference appeared to be constant at any age, thus suggesting that the susceptibility to peroxidation is not age dependent. In PD patients a significant increase in basal MDA when compared with age-matched controls was found, whereas AD patients showed a decrease of this biochemical parameter. SOD activity was significantly lower in PD patients, but showed no significant difference in AD. These results suggest that in PD patients, instead of in AD, an extracerebral involvement occurs.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalNeuroscience Research Communications
Volume25
Issue number1
DOIs
Publication statusPublished - Jul 1999

Keywords

  • Alzheimer disease
  • Free radicals
  • Lipid peroxidation
  • Malondialdheyde
  • Parkinson disease
  • Superoxide dismutase

ASJC Scopus subject areas

  • Neuroscience(all)

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