MAM-2201 (analytically confirmed) intoxication after "synthacaine" consumption

Davide Lonati; Eleonora Buscaglia; Pietro Papa; Antonella Valli; Teresa Coccini; Andrea Giampreti; Valeria Margherita Petrolini; Sarah Vecchio; Giovanni Serpelloni; Carlo Alessandro Locatelli

doi:10.1016/j.annemergmed.2014.01.007

MAM-2201 (analytically confirmed) intoxication after "synthacaine" consumption

Davide Lonati, Eleonora Buscaglia, Pietro Papa, Antonella Valli, Teresa Coccini, Andrea Giampreti, Valeria Margherita Petrolini, Sarah Vecchio, Giovanni Serpelloni, Carlo Alessandro Locatelli

Research output: Contribution to journal › Article

Abstract

Excitatory behavior, xerostomia, chest pain, severe dyspnea, tachycardia (150 beats/min), and mild hypertension (160/80 mm Hg) without ECG abnormalities were observed in a 20-year-old subject 6 hours after nasal insufflation (snorting) of a "legally" obtained white powdered substance sold as Synthacaine. A serum sample was found to contain MAM-2201 (11 ng/mL), a synthetic cannabinoid receptor agonist, and benzocaine. The patient's symptoms improved after administration of diazepam and intravenous fluids. Synthacaine was sold as legal cocaine, suggesting the user can expect an effect like that of cocaine. The pharmacologic receptor profile and chemical structure of MAM-2201 is similar to the synthetic cannabinoid receptor agonists AM-2201 and JWH-122 (2 potent synthetic cannabinoid receptor agonists with high affinity to cannabinoid receptors).

Original language	English
Pages (from-to)	629-632
Number of pages	4
Journal	Annals of Emergency Medicine
Volume	64
Issue number	6
DOIs	https://doi.org/10.1016/j.annemergmed.2014.01.007
Publication status	Published - Dec 1 2014

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ASJC Scopus subject areas

Emergency Medicine
Medicine(all)

Cite this

Lonati, D., Buscaglia, E., Papa, P., Valli, A., Coccini, T., Giampreti, A., Petrolini, V. M., Vecchio, S., Serpelloni, G., & Locatelli, C. A. (2014). MAM-2201 (analytically confirmed) intoxication after "synthacaine" consumption. Annals of Emergency Medicine, 64(6), 629-632. https://doi.org/10.1016/j.annemergmed.2014.01.007

MAM-2201 (analytically confirmed) intoxication after "synthacaine" consumption. / Lonati, Davide ; Buscaglia, Eleonora ; Papa, Pietro ; Valli, Antonella ; Coccini, Teresa ; Giampreti, Andrea ; Petrolini, Valeria Margherita ; Vecchio, Sarah; Serpelloni, Giovanni; Locatelli, Carlo Alessandro.

In: Annals of Emergency Medicine, Vol. 64, No. 6, 01.12.2014, p. 629-632.

Research output: Contribution to journal › Article

Lonati, Davide ; Buscaglia, Eleonora ; Papa, Pietro ; Valli, Antonella ; Coccini, Teresa ; Giampreti, Andrea ; Petrolini, Valeria Margherita ; Vecchio, Sarah ; Serpelloni, Giovanni ; Locatelli, Carlo Alessandro. / MAM-2201 (analytically confirmed) intoxication after "synthacaine" consumption. In: Annals of Emergency Medicine. 2014 ; Vol. 64, No. 6. pp. 629-632.

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10.1016/j.annemergmed.2014.01.007