TY - JOUR
T1 - MAM-2201 (analytically confirmed) intoxication after "synthacaine" consumption
AU - Lonati, Davide
AU - Buscaglia, Eleonora
AU - Papa, Pietro
AU - Valli, Antonella
AU - Coccini, Teresa
AU - Giampreti, Andrea
AU - Petrolini, Valeria Margherita
AU - Vecchio, Sarah
AU - Serpelloni, Giovanni
AU - Locatelli, Carlo Alessandro
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Excitatory behavior, xerostomia, chest pain, severe dyspnea, tachycardia (150 beats/min), and mild hypertension (160/80 mm Hg) without ECG abnormalities were observed in a 20-year-old subject 6 hours after nasal insufflation (snorting) of a "legally" obtained white powdered substance sold as Synthacaine. A serum sample was found to contain MAM-2201 (11 ng/mL), a synthetic cannabinoid receptor agonist, and benzocaine. The patient's symptoms improved after administration of diazepam and intravenous fluids. Synthacaine was sold as legal cocaine, suggesting the user can expect an effect like that of cocaine. The pharmacologic receptor profile and chemical structure of MAM-2201 is similar to the synthetic cannabinoid receptor agonists AM-2201 and JWH-122 (2 potent synthetic cannabinoid receptor agonists with high affinity to cannabinoid receptors).
AB - Excitatory behavior, xerostomia, chest pain, severe dyspnea, tachycardia (150 beats/min), and mild hypertension (160/80 mm Hg) without ECG abnormalities were observed in a 20-year-old subject 6 hours after nasal insufflation (snorting) of a "legally" obtained white powdered substance sold as Synthacaine. A serum sample was found to contain MAM-2201 (11 ng/mL), a synthetic cannabinoid receptor agonist, and benzocaine. The patient's symptoms improved after administration of diazepam and intravenous fluids. Synthacaine was sold as legal cocaine, suggesting the user can expect an effect like that of cocaine. The pharmacologic receptor profile and chemical structure of MAM-2201 is similar to the synthetic cannabinoid receptor agonists AM-2201 and JWH-122 (2 potent synthetic cannabinoid receptor agonists with high affinity to cannabinoid receptors).
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U2 - 10.1016/j.annemergmed.2014.01.007
DO - 10.1016/j.annemergmed.2014.01.007
M3 - Article
C2 - 24530110
AN - SCOPUS:84914112407
VL - 64
SP - 629
EP - 632
JO - Annals of Emergency Medicine
JF - Annals of Emergency Medicine
SN - 0196-0644
IS - 6
ER -