Mammalian augmenter of liver regeneration and variants thereof

Antonio T. Francavilla, Michio Hagiya, Thomas E. Starzl

Research output: Contribution to journalArticlepeer-review

Abstract

Full-length cDNA clones have been isolated encoding purified augmenter of liver regeneration (ALR) polypeptides prepared from the cytosol of livers from weanling rats and from humans. The full-length clone from the rat is a 1226 bp cDNA containing an 81 bp 5′-untranslated region, a 594 bp coding region and a 551 bp 3′-untranslated region. The coding region encodes three proteins with estimated molecular weights of 15,081, 20,193 and 22,835. The full-length clone from the human consists of a 727 bp cDNA containing a 4 bp 5′-untranslated region, a 615 bp coding region and a 108 bp 3′-untranslated region, including the termination codon TAG and the poly (A) region. The 615 bp coding region encodes four proteins, human ALR-V1, ALR-V2, ALR-V3 and ALR, having estimated molecular weights of 23,448, 20,834, 20,703 and 15,028, respectively.

Original languageEnglish
Pages (from-to)678
Number of pages1
JournalBiotechnology Advances
Volume15
Issue number3-4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Biotechnology

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