Mammalian augmenter of liver regeneration and variants thereof

Antonio T. Francavilla, Michio Hagiya, Thomas E. Starzl

Research output: Contribution to journalArticle

Abstract

Full-length cDNA clones have been isolated encoding purified augmenter of liver regeneration (ALR) polypeptides prepared from the cytosol of livers from weanling rats and from humans. The full-length clone from the rat is a 1226 bp cDNA containing an 81 bp 5′-untranslated region, a 594 bp coding region and a 551 bp 3′-untranslated region. The coding region encodes three proteins with estimated molecular weights of 15,081, 20,193 and 22,835. The full-length clone from the human consists of a 727 bp cDNA containing a 4 bp 5′-untranslated region, a 615 bp coding region and a 108 bp 3′-untranslated region, including the termination codon TAG and the poly (A) region. The 615 bp coding region encodes four proteins, human ALR-V1, ALR-V2, ALR-V3 and ALR, having estimated molecular weights of 23,448, 20,834, 20,703 and 15,028, respectively.

Original languageEnglish
Pages (from-to)678
Number of pages1
JournalBiotechnology Advances
Volume15
Issue number3-4
Publication statusPublished - 1997

Fingerprint

Liver Regeneration
Liver
Complementary DNA
Clone Cells
5' Untranslated Regions
3' Untranslated Regions
Molecular Weight
Rats
Poly A
Molecular weight
Terminator Codon
Cytosol
Proteins
Polypeptides
Peptides

ASJC Scopus subject areas

  • Biotechnology

Cite this

Francavilla, A. T., Hagiya, M., & Starzl, T. E. (1997). Mammalian augmenter of liver regeneration and variants thereof. Biotechnology Advances, 15(3-4), 678.

Mammalian augmenter of liver regeneration and variants thereof. / Francavilla, Antonio T.; Hagiya, Michio; Starzl, Thomas E.

In: Biotechnology Advances, Vol. 15, No. 3-4, 1997, p. 678.

Research output: Contribution to journalArticle

Francavilla, AT, Hagiya, M & Starzl, TE 1997, 'Mammalian augmenter of liver regeneration and variants thereof', Biotechnology Advances, vol. 15, no. 3-4, pp. 678.
Francavilla AT, Hagiya M, Starzl TE. Mammalian augmenter of liver regeneration and variants thereof. Biotechnology Advances. 1997;15(3-4):678.
Francavilla, Antonio T. ; Hagiya, Michio ; Starzl, Thomas E. / Mammalian augmenter of liver regeneration and variants thereof. In: Biotechnology Advances. 1997 ; Vol. 15, No. 3-4. pp. 678.
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