Mammalian nerve globins in search of functions

Paolo Ascenzi, Stefano Gustincich, Maria Marino

Research output: Contribution to journalArticle

Abstract

Nerve globins are present in nonvertebrates and vertebrates, the first nerve globin having been recognized in the nerve cord of the polychaete annelid Aphrodite aculeata in 1872. Later, in 2000, the first vertebrate nerve globin, named neuroglobin (Ngb), has been identified in neuronal tissues of humans and mice. Recently, cytoglobin, hemoglobin, and myoglobin have also been reported to be expressed in the mammalian nervous system. The concentration of mammalian nerve globins is ∼1 μM, with the exception of Ngb that reaches approximately 100-200 μM only in the retina rod cells. Mammalian nerve globins have been hypothesized to be involved in the excitability of the nervous system, in the metabolism of reactive nitrogen and oxygen species, and in intracellular signaling pathways leading to the neuronal cell survival. Only in retina cells, mammalian Ngb may help to sustain O2 supply to mitochondria, thereby supporting the visual process in the eye. Here, the putative roles of mammalian nerve globins are reviewed.

Original languageEnglish
Pages (from-to)268-276
Number of pages9
JournalIUBMB Life
Volume66
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Globins
Neurology
Nervous System
Vertebrates
Retinal Rod Photoreceptor Cells
Reactive Nitrogen Species
Mitochondria
Myoglobin
Metabolism
Retina
Reactive Oxygen Species
Cell Survival
Hemoglobins
Cells
Tissue
neuroglobin

Keywords

  • cytoglobin
  • globins
  • hemoglobin
  • mammalian nervous system
  • myoglobin
  • neuroglobin

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics
  • Medicine(all)

Cite this

Ascenzi, P., Gustincich, S., & Marino, M. (2014). Mammalian nerve globins in search of functions. IUBMB Life, 66(4), 268-276. https://doi.org/10.1002/iub.1267

Mammalian nerve globins in search of functions. / Ascenzi, Paolo; Gustincich, Stefano; Marino, Maria.

In: IUBMB Life, Vol. 66, No. 4, 2014, p. 268-276.

Research output: Contribution to journalArticle

Ascenzi, P, Gustincich, S & Marino, M 2014, 'Mammalian nerve globins in search of functions', IUBMB Life, vol. 66, no. 4, pp. 268-276. https://doi.org/10.1002/iub.1267
Ascenzi P, Gustincich S, Marino M. Mammalian nerve globins in search of functions. IUBMB Life. 2014;66(4):268-276. https://doi.org/10.1002/iub.1267
Ascenzi, Paolo ; Gustincich, Stefano ; Marino, Maria. / Mammalian nerve globins in search of functions. In: IUBMB Life. 2014 ; Vol. 66, No. 4. pp. 268-276.
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