Abstract
The two anthracycline antitumor antibiotics, Adriamycin and daunomycin (DM), induced a high incidence of mammary tumors, both fibroadenomas and adenocarcinomas, in female rats that received a single i.v. dose, thus confirming previous results. The incidence of DM-induced adenocarcinomas increased with the dose of the drug, whereas the incidence of Adriamycin-induced adenocarcinomas showed a plateau at 5 mg/kg and above. Adriamycin- and DM-induced fibroadenomas showed a peak at lower doses (about 5 to 6 mg/kg). With the highest DM dose (12.5 mg/kg) used, there was a slight prevalence of adenocarcinomas over fibroadenomas.
Original language | English |
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Pages (from-to) | 1444-1446 |
Number of pages | 3 |
Journal | Cancer Research |
Volume | 38 |
Issue number | 5 |
Publication status | Published - 1978 |
ASJC Scopus subject areas
- Cancer Research
- Oncology