Mammographic density estimation

Comparison among BI-RADS categories, a semi-automated software and a fully automated one

Alberto Tagliafico, Giulio Tagliafico, Simona Tosto, Fabio Chiesa, Carlo Martinoli, Lorenzo E. Derchi, Massimo Calabrese

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Although breast density is considered a strong predictor of breast cancer risk, its quantitative assessment is difficult. The aim of this study is to demonstrate that breast density assessment with a fully automated software is feasible and correlates with the semi-automated evaluation and the quantitative BI-RADS standards. A data set of 160 mammograms was evaluated by three blinded radiologists. Intra-observer (reader 1: k = 0.71; reader 2: k = 0.76; reader 3: k = 0.62) and inter-observer (reader 1 vs reader 2: k = 0.72; reader 2 vs reader 3: k = 0.80; reader 3 vs reader 1: k = 0.72) variability for the semi-automated software were good on a four-grade scale (D1/D2/D3/D4) and correlated with BI-RADS evaluation made by other two blinded radiologists (r = 0.65, p <0.01). Inter-observer (reader 1 vs reader 2: k = 0.85; reader 2 vs reader 3: k = 0.91; reader 3 vs reader 1: k = 0.85) variability for the semi-automated software was very good on a two-grade scale (D1-D2/D3-D4). The use of the fully automated software eliminated intra- and inter-observer differences, correlated with BI-RADS categories (r = 0.62, p <0.01) and can replace the semi-automated one (Bland-Altman statistics). Our study demonstrates that automated estimation of breast density is feasible and eliminates subjectivity. Furthermore both the semi-automated and the fully automated density estimation are more accurate than BI-RADS quantitative evaluation and could also be used in the daily clinical practice.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalBreast
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2009

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Software
Breast Neoplasms
Breast Density
Radiologists

Keywords

  • Automated evaluation
  • Breast
  • Breast density
  • Inter-observer variability
  • Mammography

ASJC Scopus subject areas

  • Surgery

Cite this

Mammographic density estimation : Comparison among BI-RADS categories, a semi-automated software and a fully automated one. / Tagliafico, Alberto; Tagliafico, Giulio; Tosto, Simona; Chiesa, Fabio; Martinoli, Carlo; Derchi, Lorenzo E.; Calabrese, Massimo.

In: Breast, Vol. 18, No. 1, 02.2009, p. 35-40.

Research output: Contribution to journalArticle

Tagliafico, Alberto ; Tagliafico, Giulio ; Tosto, Simona ; Chiesa, Fabio ; Martinoli, Carlo ; Derchi, Lorenzo E. ; Calabrese, Massimo. / Mammographic density estimation : Comparison among BI-RADS categories, a semi-automated software and a fully automated one. In: Breast. 2009 ; Vol. 18, No. 1. pp. 35-40.
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