Management of acute childhood idiopathic thrombocytopenic purpura according to AIEOP consensus guidelines: Assessment of Italian experience

Giovanni Carlo Del Vecchio, Attilio De Santis, Paola Giordano, Giovanni Amendola, Carlo Baronci, Domenico Del Principe, Bruno Nobili, Momcilo Jankovic, Ugo Ramenghi, Giovanna Russo, Marco Zecca, Domenico De Mattia, Raffaella De Santis, Saverio Magro, Sofia M R Matarese, Angelo Claudio Molinari, Margherita Nardi, Luigi Nespoli, Alberto Arrighini, Paolo PaolucciGiuseppina Paone, Vincenzo Sabato, Fabio Tucci

Research output: Contribution to journalArticle

Abstract

Background: Consensus guidelines for diagnosis and treatment of acute childhood idiopathic thrombocytopenic purpura (ITP) were published in 2000 by the Italian Association of Pediatric Haematology and Oncology (AIEOP). The assessment of guideline implementation was the primary objective of the present study. Patients and Methods: Information on each newly diagnosed case of ITP referring to centres conforming with the guidelines was obtained by a questionnaire. Results: Data concerning 609 new cases of acute childhood ITP were collected including 346 (56.8%) asymptomatic-paucisymptomatic forms (type A), 262 (43%) intermediate clinical forms (type B), and 1 (0.2%) severe form (type C). At diagnosis, 82% of cases were hospitalized. Age, platelet count and duration of hospitalization were significantly different in type A and type B cases. Of the total number of cases, 25% were kept under observation, 38.6% received intravenous immunoglobulins, 23.9% oral or parenteral steroids, and 12.7% other treatments. The initial treatment turned out to be appropriate for 428 cases (72.2%), of uncertain appropriateness in 71 (11.9%), and inappropriate in 95 cases (15.9%). The total level of implementation was 84.1%. Conclusions: A high rate of guideline implementation was observed during the study period. The guidelines should be reviewed taking into account more recent evidence.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalActa Haematologica
Volume119
Issue number1
DOIs
Publication statusPublished - Mar 2008

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Idiopathic Thrombocytopenic Purpura
Guidelines
Intravenous Immunoglobulins
Hematology
Platelet Count
Hospitalization
Therapeutics
Steroids
Observation
Pediatrics

Keywords

  • Guidelines, childhood
  • Idiopathic thrombocytopenic purpura

ASJC Scopus subject areas

  • Hematology

Cite this

Del Vecchio, G. C., De Santis, A., Giordano, P., Amendola, G., Baronci, C., Del Principe, D., ... Tucci, F. (2008). Management of acute childhood idiopathic thrombocytopenic purpura according to AIEOP consensus guidelines: Assessment of Italian experience. Acta Haematologica, 119(1), 1-7. https://doi.org/10.1159/000112837

Management of acute childhood idiopathic thrombocytopenic purpura according to AIEOP consensus guidelines : Assessment of Italian experience. / Del Vecchio, Giovanni Carlo; De Santis, Attilio; Giordano, Paola; Amendola, Giovanni; Baronci, Carlo; Del Principe, Domenico; Nobili, Bruno; Jankovic, Momcilo; Ramenghi, Ugo; Russo, Giovanna; Zecca, Marco; De Mattia, Domenico; De Santis, Raffaella; Magro, Saverio; Matarese, Sofia M R; Molinari, Angelo Claudio; Nardi, Margherita; Nespoli, Luigi; Arrighini, Alberto; Paolucci, Paolo; Paone, Giuseppina; Sabato, Vincenzo; Tucci, Fabio.

In: Acta Haematologica, Vol. 119, No. 1, 03.2008, p. 1-7.

Research output: Contribution to journalArticle

Del Vecchio, GC, De Santis, A, Giordano, P, Amendola, G, Baronci, C, Del Principe, D, Nobili, B, Jankovic, M, Ramenghi, U, Russo, G, Zecca, M, De Mattia, D, De Santis, R, Magro, S, Matarese, SMR, Molinari, AC, Nardi, M, Nespoli, L, Arrighini, A, Paolucci, P, Paone, G, Sabato, V & Tucci, F 2008, 'Management of acute childhood idiopathic thrombocytopenic purpura according to AIEOP consensus guidelines: Assessment of Italian experience', Acta Haematologica, vol. 119, no. 1, pp. 1-7. https://doi.org/10.1159/000112837
Del Vecchio, Giovanni Carlo ; De Santis, Attilio ; Giordano, Paola ; Amendola, Giovanni ; Baronci, Carlo ; Del Principe, Domenico ; Nobili, Bruno ; Jankovic, Momcilo ; Ramenghi, Ugo ; Russo, Giovanna ; Zecca, Marco ; De Mattia, Domenico ; De Santis, Raffaella ; Magro, Saverio ; Matarese, Sofia M R ; Molinari, Angelo Claudio ; Nardi, Margherita ; Nespoli, Luigi ; Arrighini, Alberto ; Paolucci, Paolo ; Paone, Giuseppina ; Sabato, Vincenzo ; Tucci, Fabio. / Management of acute childhood idiopathic thrombocytopenic purpura according to AIEOP consensus guidelines : Assessment of Italian experience. In: Acta Haematologica. 2008 ; Vol. 119, No. 1. pp. 1-7.
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T1 - Management of acute childhood idiopathic thrombocytopenic purpura according to AIEOP consensus guidelines

T2 - Assessment of Italian experience

AU - Del Vecchio, Giovanni Carlo

AU - De Santis, Attilio

AU - Giordano, Paola

AU - Amendola, Giovanni

AU - Baronci, Carlo

AU - Del Principe, Domenico

AU - Nobili, Bruno

AU - Jankovic, Momcilo

AU - Ramenghi, Ugo

AU - Russo, Giovanna

AU - Zecca, Marco

AU - De Mattia, Domenico

AU - De Santis, Raffaella

AU - Magro, Saverio

AU - Matarese, Sofia M R

AU - Molinari, Angelo Claudio

AU - Nardi, Margherita

AU - Nespoli, Luigi

AU - Arrighini, Alberto

AU - Paolucci, Paolo

AU - Paone, Giuseppina

AU - Sabato, Vincenzo

AU - Tucci, Fabio

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N2 - Background: Consensus guidelines for diagnosis and treatment of acute childhood idiopathic thrombocytopenic purpura (ITP) were published in 2000 by the Italian Association of Pediatric Haematology and Oncology (AIEOP). The assessment of guideline implementation was the primary objective of the present study. Patients and Methods: Information on each newly diagnosed case of ITP referring to centres conforming with the guidelines was obtained by a questionnaire. Results: Data concerning 609 new cases of acute childhood ITP were collected including 346 (56.8%) asymptomatic-paucisymptomatic forms (type A), 262 (43%) intermediate clinical forms (type B), and 1 (0.2%) severe form (type C). At diagnosis, 82% of cases were hospitalized. Age, platelet count and duration of hospitalization were significantly different in type A and type B cases. Of the total number of cases, 25% were kept under observation, 38.6% received intravenous immunoglobulins, 23.9% oral or parenteral steroids, and 12.7% other treatments. The initial treatment turned out to be appropriate for 428 cases (72.2%), of uncertain appropriateness in 71 (11.9%), and inappropriate in 95 cases (15.9%). The total level of implementation was 84.1%. Conclusions: A high rate of guideline implementation was observed during the study period. The guidelines should be reviewed taking into account more recent evidence.

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KW - Idiopathic thrombocytopenic purpura

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