Management of acute childhood idiopathic thrombocytopenic purpura according to AIEOP consensus guidelines: Assessment of Italian experience

Giovanni Carlo Del Vecchio, Attilio De Santis, Paola Giordano, Giovanni Amendola, Carlo Baronci, Domenico Del Principe, Bruno Nobili, Momcilo Jankovic, Ugo Ramenghi, Giovanna Russo, Marco Zecca, Domenico De Mattia, Raffaella De Santis, Saverio Magro, Sofia M R Matarese, Angelo Claudio Molinari, Margherita Nardi, Luigi Nespoli, Alberto Arrighini, Paolo PaolucciGiuseppina Paone, Vincenzo Sabato, Fabio Tucci

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Consensus guidelines for diagnosis and treatment of acute childhood idiopathic thrombocytopenic purpura (ITP) were published in 2000 by the Italian Association of Pediatric Haematology and Oncology (AIEOP). The assessment of guideline implementation was the primary objective of the present study. Patients and Methods: Information on each newly diagnosed case of ITP referring to centres conforming with the guidelines was obtained by a questionnaire. Results: Data concerning 609 new cases of acute childhood ITP were collected including 346 (56.8%) asymptomatic-paucisymptomatic forms (type A), 262 (43%) intermediate clinical forms (type B), and 1 (0.2%) severe form (type C). At diagnosis, 82% of cases were hospitalized. Age, platelet count and duration of hospitalization were significantly different in type A and type B cases. Of the total number of cases, 25% were kept under observation, 38.6% received intravenous immunoglobulins, 23.9% oral or parenteral steroids, and 12.7% other treatments. The initial treatment turned out to be appropriate for 428 cases (72.2%), of uncertain appropriateness in 71 (11.9%), and inappropriate in 95 cases (15.9%). The total level of implementation was 84.1%. Conclusions: A high rate of guideline implementation was observed during the study period. The guidelines should be reviewed taking into account more recent evidence.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalActa Haematologica
Volume119
Issue number1
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Guidelines, childhood
  • Idiopathic thrombocytopenic purpura

ASJC Scopus subject areas

  • Hematology

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