Management of AIDS-related Kaposi's sarcoma

Giuseppe Di Lorenzo, Panagiotis A. Konstantinopoulos, Liron Pantanowitz, Rossella Di Trolio, Sabino De Placido, Bruce J. Dezube

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Abstract

The advent of highly active antiretroviral therapy (HAART) has lead to a substantial reduction in the prevalence, morbidity, and mortality associated with AIDS-related Kaposi's sarcoma. Similarly, concomitant advances in chemotherapy and supportive-care protocols have allowed for Kaposi's sarcoma to be managed more effectively in comparison with the pre-HAART era. Furthermore, developments in our understanding of the pathogenesis of Kaposi's sarcoma have identified several molecular targets that can potentially provide new therapeutic strategies. This Review discusses the role of conventional chemotherapeutic and immunomodulatory agents in the treatment of Kaposi's sarcoma and summarises the current status and future prospects of novel molecularly targeted agents in the treatment of this disease.

Original languageEnglish
Pages (from-to)167-176
Number of pages10
JournalThe Lancet Oncology
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 2007

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ASJC Scopus subject areas

  • Oncology

Cite this

Di Lorenzo, G., Konstantinopoulos, P. A., Pantanowitz, L., Di Trolio, R., De Placido, S., & Dezube, B. J. (2007). Management of AIDS-related Kaposi's sarcoma. The Lancet Oncology, 8(2), 167-176. https://doi.org/10.1016/S1470-2045(07)70036-0