Management of bleeding disorders in adults

F. Peyvandi, R. Klamroth, M. Carcao, A. B. Federici, G. Di Minno, V. Jiménez-Yuste, E. C. Rodriguez Merchán

Research output: Contribution to journalArticle

Abstract

Development of FVIII inhibitors is currently the most severe and challenging complication of haemophilia A treatment and represents a very large economic burden for a chronic disease. As a result, clinical research is making major efforts to optimize the therapeutic approaches for this condition. In this section we will review some important aspects of the management of haemophilia in adults, including an overview of bleeding in women with von Willebrand disease, an analysis of FVIII consumption in patients with severe haemophilia A, an update of the ongoing RES.I.ST study, long-term prophylaxis and experience from the Pro.Will study, current evidence relating to economic aspects of the treatment of haemophilic patients with inhibitors (based on the PROFIT study), and an overview of musculoskeletal complications in adults with severe bleeding disorders.

Original languageEnglish
Pages (from-to)24-36
Number of pages13
JournalHaemophilia
Volume18
Issue numberSUPPL. 2
DOIs
Publication statusPublished - May 2012

Keywords

  • Adults
  • Cost-effectiveness
  • FVIII consumption
  • Haemophilia A
  • Inhibitor development
  • Prophylaxis

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

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  • Cite this

    Peyvandi, F., Klamroth, R., Carcao, M., Federici, A. B., Di Minno, G., Jiménez-Yuste, V., & Rodriguez Merchán, E. C. (2012). Management of bleeding disorders in adults. Haemophilia, 18(SUPPL. 2), 24-36. https://doi.org/10.1111/j.1365-2516.2012.02797.x