Management of chronic childhood immune thrombocytopenic purpura: AIEOP consensus guidelines

Domenico De Mattia, Giovanni Carlo Del Vecchio, Giovanna Russo, Attilio De Santis, Ugo Ramenghi, Lucia Notarangelo, Momcilo Jankovic, Angelo Claudio Molinari, Marco Zecca, Bruno Nobili, Paola Giordano, A. Acquaviva, G. Amendola, C. Baronci, S. Binda, G. Bisogno, C. Bussetti, A. Ciliberti, M. Citterio, D. Del PrincipeP. Farruggia, S. Ladogana, S. Magro, G. Masera, A. Menichelli, M. Nardi, E. Parodi, A. Pession, F. Tucci, C. Vimercati

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Objective: The management of chronic childhood idiopathic thrombocytopenic purpura (ITP) is distinct from acute ITP. Similar to the publication on acute ITP guidelines, the AIEOP (Associazione Italiana di Ematologia e Oncologia Pediatrica) considered it appropriate to develop consensus guidelines for chronic childhood ITP to provide useful and shared information for physicians, healthcare professionals, parents and patients. Design/Methods: A preliminary, evidence-based document issued by a select group of AIEOP pediatric hematologists was discussed, modified and approved during a Consensus Conference according to procedures previously validated by the AIEOP Board. Results: The guidelines give prominence to the periodical reevaluation of all the etiological hypotheses of thrombocytopenia in relation to its clinical condition. The majority of chronic ITP children do not require treatment, especially if bleeding is absent or minimal. The treatment decision depends on several factors other than the platelet count, and treatment options are suggested in relation to the therapeutic scenarios. Recommendations are given regarding support for surgery, particular hemorrhagic conditions, daily activities/sports, as well as for vaccines and drugs. Experimental treatments are also discussed.

Original languageEnglish
Pages (from-to)96-109
Number of pages14
JournalActa Haematologica
Volume123
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Idiopathic thrombocytopenic purpura
  • Management of pediatric thrombocytopenia
  • Pediatric thrombocytopenia
  • Platelet count
  • Thrombocytopenia

ASJC Scopus subject areas

  • Hematology

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