TY - JOUR
T1 - Management of chronic childhood immune thrombocytopenic purpura
T2 - AIEOP consensus guidelines
AU - De Mattia, Domenico
AU - Del Vecchio, Giovanni Carlo
AU - Russo, Giovanna
AU - De Santis, Attilio
AU - Ramenghi, Ugo
AU - Notarangelo, Lucia
AU - Jankovic, Momcilo
AU - Molinari, Angelo Claudio
AU - Zecca, Marco
AU - Nobili, Bruno
AU - Giordano, Paola
AU - Acquaviva, A.
AU - Amendola, G.
AU - Baronci, C.
AU - Binda, S.
AU - Bisogno, G.
AU - Bussetti, C.
AU - Ciliberti, A.
AU - Citterio, M.
AU - Del Principe, D.
AU - Farruggia, P.
AU - Ladogana, S.
AU - Magro, S.
AU - Masera, G.
AU - Menichelli, A.
AU - Nardi, M.
AU - Parodi, E.
AU - Pession, A.
AU - Tucci, F.
AU - Vimercati, C.
PY - 2010/2
Y1 - 2010/2
N2 - Background/Objective: The management of chronic childhood idiopathic thrombocytopenic purpura (ITP) is distinct from acute ITP. Similar to the publication on acute ITP guidelines, the AIEOP (Associazione Italiana di Ematologia e Oncologia Pediatrica) considered it appropriate to develop consensus guidelines for chronic childhood ITP to provide useful and shared information for physicians, healthcare professionals, parents and patients. Design/Methods: A preliminary, evidence-based document issued by a select group of AIEOP pediatric hematologists was discussed, modified and approved during a Consensus Conference according to procedures previously validated by the AIEOP Board. Results: The guidelines give prominence to the periodical reevaluation of all the etiological hypotheses of thrombocytopenia in relation to its clinical condition. The majority of chronic ITP children do not require treatment, especially if bleeding is absent or minimal. The treatment decision depends on several factors other than the platelet count, and treatment options are suggested in relation to the therapeutic scenarios. Recommendations are given regarding support for surgery, particular hemorrhagic conditions, daily activities/sports, as well as for vaccines and drugs. Experimental treatments are also discussed.
AB - Background/Objective: The management of chronic childhood idiopathic thrombocytopenic purpura (ITP) is distinct from acute ITP. Similar to the publication on acute ITP guidelines, the AIEOP (Associazione Italiana di Ematologia e Oncologia Pediatrica) considered it appropriate to develop consensus guidelines for chronic childhood ITP to provide useful and shared information for physicians, healthcare professionals, parents and patients. Design/Methods: A preliminary, evidence-based document issued by a select group of AIEOP pediatric hematologists was discussed, modified and approved during a Consensus Conference according to procedures previously validated by the AIEOP Board. Results: The guidelines give prominence to the periodical reevaluation of all the etiological hypotheses of thrombocytopenia in relation to its clinical condition. The majority of chronic ITP children do not require treatment, especially if bleeding is absent or minimal. The treatment decision depends on several factors other than the platelet count, and treatment options are suggested in relation to the therapeutic scenarios. Recommendations are given regarding support for surgery, particular hemorrhagic conditions, daily activities/sports, as well as for vaccines and drugs. Experimental treatments are also discussed.
KW - Idiopathic thrombocytopenic purpura
KW - Management of pediatric thrombocytopenia
KW - Pediatric thrombocytopenia
KW - Platelet count
KW - Thrombocytopenia
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U2 - 10.1159/000268855
DO - 10.1159/000268855
M3 - Article
C2 - 20029174
AN - SCOPUS:72149113344
VL - 123
SP - 96
EP - 109
JO - Acta Haematologica
JF - Acta Haematologica
SN - 0001-5792
IS - 2
ER -