Management of chronic inflammatory demyelinating polyradiculopathy

Research output: Contribution to journalArticle

Abstract

PURPOSE OF REVIEW: To review the recent advances in the management and treatment of chronic inflammatory demyelinating polyradiculopathy (CIDP).

RECENT FINDINGS: Recent studies confirm the efficacy/safety of long-term intravenous immunoglobulin (IVIg) and short-term subcutaneous immunoglobulin (SCIg) therapy in CIDP. New outcome measures have been recently proposed and further studies evaluated the properties of those already in use. The presence of antibodies against proteins at the node of Ranvier was associated with specific clinical features and treatment response. Fingolimod adds to the list of immunosuppressive agents that failed to be effective in a controlled trial.

SUMMARY: Several studies evaluating the best strategy to provide maintenance IVIg treatment in CIDP are in progress. SCIg were shown to be an alternative to IVIg for maintenance treatment while their efficacy as initial therapy should be further addressed. New outcome measures have been shown to be effective in detecting treatment response in clinical trials, but their use in clinical practice remains uncertain. Similarly unsettled is the role of nerve imaging techniques as biomarker in CIDP. The discovery of antibodies against proteins at the node of Ranvier has rekindled a keen interest in the pathogenesis of CIDP and the potential therapeutic role of new agents.

Original languageEnglish
Pages (from-to)511-516
Number of pages6
JournalCurrent Opinion in Neurology
Volume31
Issue number5
DOIs
Publication statusPublished - Oct 2018

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Intravenous Immunoglobulins
Ranvier's Nodes
Therapeutics
Outcome Assessment (Health Care)
Passive Immunization
Antibodies
Immunosuppressive Agents
Immunoglobulins
Proteins
Biomarkers
Maintenance
Clinical Trials
Safety

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Management of chronic inflammatory demyelinating polyradiculopathy. / Doneddu, Pietro E; Nobile-Orazio, Eduardo.

In: Current Opinion in Neurology, Vol. 31, No. 5, 10.2018, p. 511-516.

Research output: Contribution to journalArticle

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