Management of diabetes insipidus and adipsia in the child

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Central diabetes insipidus (CDI) is a complex and heterogeneous clinical syndrome affecting the hypothalamic-neurohypophyseal network and water balance. A recent national surveillance in Denmark showed a prevalence rate of twenty-three CDI patients per 100 000 inhabitants in five years. The differential diagnosis between several presenting conditions with polyuria and polydipsia is puzzling, and the etiological diagnosis of CDI remains a challenge before the identification of an underlying cause. For clinical practice, a timely diagnosis for initiating specific treatment in order to avoid central nervous system damage, additional pituitary defects and the risk of dissemination of germ cell tumor is advisable. Proper etiological diagnosis can be achieved via a series of steps that start with careful clinical observation of several signs and endocrine symptoms and then progress to more sophisticated imaging tools. This review summarizes the best practice and approach for the diagnosis and treatment of patients with CDI.

Original languageEnglish
Pages (from-to)415-436
Number of pages22
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Issue number3
Publication statusPublished - Jun 1 2015


  • adipsia
  • anterior pituitary
  • desmopressin
  • diabetes insipidus
  • germ cell tumors
  • langerhans cell histiocytosis
  • pituitary stalk
  • polydipsia
  • polyuria
  • posterior pituitary

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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