Management of hepatic epithelioid haemangio-endothelioma in children: What option?

K. Sharif, M. English, P. Ramani, D. Alberti, J. B. Otte, P. McKiernan, S. Gosseye, M. Jenney, J. De Ville De Goyet

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Hepatic epithelioid haemangio-endothelioma (HEHE) is an endothelium-derived tumour of low-to-medium grade malignancy. It is predominantly seen in adults and is unresponsive to chemotherapy. Liver transplantation is an accepted indication when the tumour is unresectable. Hepatic epithelioid haemangio-endothelioma is very rare in children and results after transplantation are not reported. The aim of this study is to review the experience of three European centres in the management of HEHE in children. A retrospective review of all paediatric patients with HEHE managed in three European centres is presented. Five children were identified. Four had unresectable tumours. The first had successful resection followed by chemotherapy and is alive, without disease 3 years after diagnosis. One child died of sepsis and one of tumour recurrence in the graft and lungs 2 and 5 months, respectively, after transplant. Two children who had progressive disease with ifosfamide-based chemotherapy have had a reduction in clinical symptoms and stabilisation of disease up to 18 and 24 months after the use of platinum-based chemotherapy. HEHE seems more aggressive in children than reported in adults and the curative role of transplantation must be questioned. Ifosfamide-based chemotherapy was not effective. Further studies are necessary to confirm if HEHE progression in children may be influenced by platinum-based chemotherapy.

Original languageEnglish
Pages (from-to)1498-1501
Number of pages4
JournalBritish Journal of Cancer
Volume90
Issue number8
DOIs
Publication statusPublished - Apr 19 2004

Fingerprint

Hemangioendothelioma
Liver
Drug Therapy
Ifosfamide
Neoplasms
Platinum
Transplantation
Transplants
Liver Transplantation
Endothelium
Sepsis
Pediatrics
Recurrence
Lung

Keywords

  • Actinomycin D
  • Adriamycin
  • Carboplatin
  • Chemotherapy
  • Cisplatin
  • Etoposide
  • Hepatic epithelioid haemangio-endothelioma
  • Ifosfamide
  • Liver transplantation
  • Liver tumour
  • Vincristine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sharif, K., English, M., Ramani, P., Alberti, D., Otte, J. B., McKiernan, P., ... De Ville De Goyet, J. (2004). Management of hepatic epithelioid haemangio-endothelioma in children: What option? British Journal of Cancer, 90(8), 1498-1501. https://doi.org/10.1038/sj.bjc.6601720

Management of hepatic epithelioid haemangio-endothelioma in children : What option? / Sharif, K.; English, M.; Ramani, P.; Alberti, D.; Otte, J. B.; McKiernan, P.; Gosseye, S.; Jenney, M.; De Ville De Goyet, J.

In: British Journal of Cancer, Vol. 90, No. 8, 19.04.2004, p. 1498-1501.

Research output: Contribution to journalArticle

Sharif, K, English, M, Ramani, P, Alberti, D, Otte, JB, McKiernan, P, Gosseye, S, Jenney, M & De Ville De Goyet, J 2004, 'Management of hepatic epithelioid haemangio-endothelioma in children: What option?', British Journal of Cancer, vol. 90, no. 8, pp. 1498-1501. https://doi.org/10.1038/sj.bjc.6601720
Sharif K, English M, Ramani P, Alberti D, Otte JB, McKiernan P et al. Management of hepatic epithelioid haemangio-endothelioma in children: What option? British Journal of Cancer. 2004 Apr 19;90(8):1498-1501. https://doi.org/10.1038/sj.bjc.6601720
Sharif, K. ; English, M. ; Ramani, P. ; Alberti, D. ; Otte, J. B. ; McKiernan, P. ; Gosseye, S. ; Jenney, M. ; De Ville De Goyet, J. / Management of hepatic epithelioid haemangio-endothelioma in children : What option?. In: British Journal of Cancer. 2004 ; Vol. 90, No. 8. pp. 1498-1501.
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