TY - JOUR
T1 - Management of impulse control disorders in Parkinson's disease
T2 - Controversies and future approaches
AU - Samuel, Michael
AU - Rodriguez-Oroz, Maria
AU - Antonini, Angelo
AU - Brotchie, Jonathan M.
AU - Ray Chaudhuri, Kallol
AU - Brown, Richard G.
AU - Galpern, Wendy R.
AU - Nirenberg, Melissa J.
AU - Okun, Michael S.
AU - Lang, Anthony E.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Impulse control disorders in Parkinson's disease are a group of impulsive behaviors most often associated with dopaminergic treatment. Presently, there is a lack of high quality evidence available to guide their management. This manuscript reviews current management strategies, before concentrating on the concept of dopamine agonist withdrawal syndrome and its implications for the management of impulse control disorders. Further, we focus on controversies, including the role of more recently available anti-parkinsonian drugs, and potential future approaches involving routes of drug delivery, nonpharmacological treatments (such as cognitive behavioral therapy and deep brain stimulation), and other as yet experimental strategies.
AB - Impulse control disorders in Parkinson's disease are a group of impulsive behaviors most often associated with dopaminergic treatment. Presently, there is a lack of high quality evidence available to guide their management. This manuscript reviews current management strategies, before concentrating on the concept of dopamine agonist withdrawal syndrome and its implications for the management of impulse control disorders. Further, we focus on controversies, including the role of more recently available anti-parkinsonian drugs, and potential future approaches involving routes of drug delivery, nonpharmacological treatments (such as cognitive behavioral therapy and deep brain stimulation), and other as yet experimental strategies.
KW - Clinical Trials
KW - Deep Brain Stimulation
KW - Dopamine Agonist Withdrawal
KW - Impulse control
KW - Management
KW - Parkinson's
UR - http://www.scopus.com/inward/record.url?scp=84964239623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964239623&partnerID=8YFLogxK
U2 - 10.1002/mds.26099
DO - 10.1002/mds.26099
M3 - Article
C2 - 25607799
AN - SCOPUS:84964239623
VL - 30
SP - 150
EP - 159
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 2
ER -