Management of infectious complications in multiple myeloma patients: Expert panel consensus-based recommendations

Corrado Girmenia, Michele Cavo, Massimo Offidani, Francesco Scaglione, Alessandro Corso, Francesco Di Raimondo, Pellegrino Musto, Maria Teresa Petrucci, Giovanni Barosi

Research output: Contribution to journalReview article

Abstract

The introduction of new therapeutic agents in multiple myeloma (MM), including proteasome inhibitors, immunoregulatory drugs and monoclonal antibodies, has improved the outcomes of patients, but in parallel has changed the frequency and epidemiology of infections. Hence, the great strides in the indications and use of new active treatments for MM need parallel progresses on the best approach to prophylaxis and supportive therapy for infections. Moving from the recognition that the above issue represents an unmet clinical need in MM, an expert panel assessed the scientific literature and composed a framework of recommendations for optimal infection control in patients candidate to active treatment for MM. The present publication represents a consensus document from questionnaires and consensus meetings held during 2017. The issues tackled in the project dealt with: infectious risk assessment, risk management and prophylaxis, intravenous immunoglobulin replacement therapy, antiviral and antibacterial vaccination. Considering the lack of conclusive and/or enough large studies for certain topics several recommendations derived from the personal experience of the experts.

Original languageEnglish
Pages (from-to)84-94
Number of pages11
JournalBlood Reviews
Volume34
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Anti-Infective Agents/therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols/adverse effects
  • Consensus
  • Disease Management
  • Expert Testimony
  • Humans
  • Immunoglobulins, Intravenous
  • Incidence
  • Infection/diagnosis
  • Infection Control/methods
  • Multiple Myeloma/complications
  • Practice Guidelines as Topic
  • Premedication
  • Vaccines/therapeutic use

Fingerprint Dive into the research topics of 'Management of infectious complications in multiple myeloma patients: Expert panel consensus-based recommendations'. Together they form a unique fingerprint.

  • Cite this

    Girmenia, C., Cavo, M., Offidani, M., Scaglione, F., Corso, A., Di Raimondo, F., Musto, P., Petrucci, M. T., & Barosi, G. (2019). Management of infectious complications in multiple myeloma patients: Expert panel consensus-based recommendations. Blood Reviews, 34, 84-94. https://doi.org/10.1016/j.blre.2019.01.001