Management of iron deficiency in renal anemia: Guidelines for the optimal therapeutic approach in erythropoietin-treated patients

T. B. Drüeke, P. Bárány, M. Cazzola, J. W. Eschbach, P. Grützmacher, J. P. Kaltwasser, I. C. Macdougall, M. J. Pippard, S. Shaldon, D. Van Wyck

Research output: Contribution to journalArticle

Abstract

Much progress has been made in recent years in the management of anemia associated with chronic renal failure with recombinant human erythropoietin (r-Hu EPO). However, there remains much debate surrounding the diagnosis and treatment of iron deficiency. To ensure that full benefit from erythropoietin therapy is received, most patients require iron supplement during treatment. There are, however, few guidelines for the use of iron therapy. Iron deficiency results in an inadequate response to r-Hu EPO and is the main cause of resistance to this treatment. Oral iron therapy is of limited value in patients receiving r-Hu EPO. Thus, intravenous iron supplementation should be administered only in patients who do not tolerate available intravenous iron preparations or who are on continuous ambulatory peritoneal dialysis with no evidence of functional iron deficiency. This article provides guidelines for the diagnosis of absolute or functional iron deficiency in patients with renal anemia and suggests treatment schedules for intravenous iron supplementation. We hope that all dialysis patients will be able on this basis to achieve a satisfactory iron status and benefit fully from r-Hu EPO therapy.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalClinical Nephrology
Volume48
Issue number1
Publication statusPublished - 1997

Keywords

  • Erythropoietin
  • Iron deficiency
  • Iron supplementation
  • Renal anemia

ASJC Scopus subject areas

  • Nephrology

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    Drüeke, T. B., Bárány, P., Cazzola, M., Eschbach, J. W., Grützmacher, P., Kaltwasser, J. P., Macdougall, I. C., Pippard, M. J., Shaldon, S., & Van Wyck, D. (1997). Management of iron deficiency in renal anemia: Guidelines for the optimal therapeutic approach in erythropoietin-treated patients. Clinical Nephrology, 48(1), 1-8.