Management of italian patients with advanced non-small-cell lung cancer after second-line treatment: Results of the longitudinal phase of the life observational study

Filippo De Marinis, Andrea Ardizzoni, Gabriella Fontanini, Francesco Grossi, Federico Cappuzzo, Silvia Novello, Antonio Santo, Vito Lorusso, Diego Cortinovis, Monica Iurlaro, Domenico Galetta, Cesare Gridelli

Research output: Contribution to journalArticle

Abstract

Results The longitudinal phase was conducted between January and August 2012. Of 464 patients who began second-line therapy outside of clinical trials within the baseline evaluation, 56 (12.1%) were still receiving second-line therapy at the end of the observation period and 17 (3.7%) withdrew during or after second-line therapy. Of the remaining 391 patients, 158 (40.4%) received third-line treatment outside of clinical trials: 93 received a third-line chemotherapy and 65 a targeted agent. The main reason for interrupting third-line treatment was disease progression or death. During the same observation period, 25 of 113 patients who completed a third-line therapy received a fourth line of treatment. From diagnosis of NSCLC to the end of observation, biomarkers were tested in 323 patients (59.7%): epidermal growth factor receptor mutations in 315 (58.2%), Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutations in 83 (15.3%) and Anaplastic lymphoma kinase (ALK) translocation in 84 (15.5%).

Conclusion In Italian clinical practice, the proportion of patients with advanced NSCLC receiving more than 2 treatment lines of therapy is not negligible.

Patients and Methods In the longitudinal phase, described here, the primary aim was to determine the proportion of patients receiving third-line therapy among those who received second-line active treatment according to clinical practice. The proportion of patients receiving further treatment lines was also estimated.

Introduction/Background Patients with advanced NSCLC who experience disease progression after second-line therapy might receive further active treatment. LIFE was an Italian cohort multicenter observational study composed of a cross-sectional and a longitudinal phase.

Original languageEnglish
Pages (from-to)338-345.e1
JournalClinical Lung Cancer
Volume15
Issue number5
DOIs
Publication statusPublished - Sep 1 2014

Keywords

  • Chemotherapy
  • EGFR
  • Erlotinib
  • NSCLC
  • Third-line

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

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