Management of kidney transplantation in a factor VII-deficient patient: Case report

M. Lapecorella, M. Napolitano, A. Lucchesi, F. Pisani, K. Clemente, V. Rizza, A. Famulari, L. Aloisio, F. Bernardi, M. Pinotti, P. Ferraresi, P. Di Cocco

Research output: Contribution to journalArticlepeer-review

Abstract

Transplantation in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Renal transplantation, the most frequent type of solid organ transplantation, is rarely performed in individuals with congenital hemorrhagic disorders. We performed a renal transplantation in a 53-year-old man with end-stage renal disease and congenital coagulation factor VII deficiency, a rare bleeding disorder with a peculiar clinical picture requiring replacement therapy in surgical interventions. Perioperative bleeding was successfully prevented by administration of recombinant activated factor VII. Treatment schedule, administration rate, and long-term follow-up are reported in detail. Our report confirmed the feasibility and safety of recombinant activated factor VII in major surgical procedures like solid organ transplantations. Success requires evaluation of doses and therapeutic schedules as well as a multidisciplinary approach.

Original languageEnglish
Pages (from-to)2033-2035
Number of pages3
JournalTransplantation Proceedings
Volume44
Issue number7
DOIs
Publication statusPublished - Sep 2012

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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