Management of locally advanced non-small cell lung cancer in the modern era: A national Italian survey on diagnosis, treatment and multidisciplinary approach

Alessio Bruni, Niccolò Giaj-Levra, Patrizia Ciammella, Virginia Maragna, Katia Ferrari, Viola Bonti, Francesco Grossi, Stefania Greco, Carlo Greco, Paolo Borghetti, Davide Franceschini, Enrica Capelletto, Marco Perna, Giuseppe Banna, Stefano Vagge, Editta Baldini, Emilio Bria, Andrea Botti, Marcello Tiseo, Massimiliano PaciMaria Taraborrelli, Venerino Poletti, Pierluigi Granone, Umberto Ricardi, Silvia Novello, Vieri Scotti

Research output: Contribution to journalArticle

Abstract

Concurrent chemotherapy and radiotherapy (cCRT) is considered the standard treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Unfortunately, management is still heterogeneous across different specialists. A multidisciplinary approach is needed in this setting due to recent, promising results obtained by consolidative immunotherapy. The aim of this survey is to assess current LA-NSCLC management in Italy. From January to April 2018, a 15-question survey focusing on diagnostic/therapeutic LA-NSCLC management was sent to 1,478 e-mail addresses that belonged to pneumologists, thoracic surgeons, and radiation and medical oncologists. 421 answers were analyzed: 176 radiation oncologists, 86 medical oncologists, 92 pneumologists, 64 thoracic surgeons and 3 other specialists. More than a half of the respondents had been practicing for >10 years after completing residency training. Some discrepancies were observed in clinical LA-NSCLC management: the lack of a regularly planned multidisciplinary tumor board, the use of upfront surgery in multistation stage IIIA, and territorial diffusion of cCRT in unresectable LA-NSCLC. Our analysis demonstrated good compliance with international guidelines in the diagnostic workup of LA-NSCLC. We observed a relationship between high clinical experience and good clinical practice. A multidisciplinary approach is mandatory for managing LA-NSCLC.

Original languageEnglish
Article numbere0224027
JournalPLoS One
Volume14
Issue number11
DOIs
Publication statusPublished - Jan 1 2019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Bruni, A., Giaj-Levra, N., Ciammella, P., Maragna, V., Ferrari, K., Bonti, V., Grossi, F., Greco, S., Greco, C., Borghetti, P., Franceschini, D., Capelletto, E., Perna, M., Banna, G., Vagge, S., Baldini, E., Bria, E., Botti, A., Tiseo, M., ... Scotti, V. (2019). Management of locally advanced non-small cell lung cancer in the modern era: A national Italian survey on diagnosis, treatment and multidisciplinary approach. PLoS One, 14(11), [e0224027]. https://doi.org/10.1371/journal.pone.0224027