Management of mucinous cystic neoplasms of the pancreas

Mario Testini, Angela Gurrado, Germana Lissidini, Pietro Venezia, Luigi Greco, Giuseppe Piccinni

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to investigate the actual management of mucinous cystic neoplasm (MCN) of the pancreas. A systematic review was performed in December 2009 by consulting PubMed MEDLINE for publications and matching the key words "pancreatic mucinous cystic neoplasm", "pancreatic mucinous cystic tumour", "pancreatic mucinous cystic mass", "pancreatic cyst", and "pancreatic cystic neoplasm" to identify English language articles describing the diagnosis and treatment of the mucinous cystic neoplasm of the pancreas. In total, 16 322 references ranging from January 1969 to December 2009 were analysed and 77 articles were identified. No articles published before 1996 were selected because MCNs were not previously considered to be a completely autonomous disease. Definition, epidemiology, anatomopathological findings, clinical presentation, preoperative evaluation, treatment and prognosis were reviewed. MCNs are pancreatic mucinproducing cysts with a distinctive ovarian-type stroma localized in the body-tail of the gland and occurring in middle-aged females. The majority of MCNs are slow growing and asymptomatic. The prevalence of invasive carcinoma varies between 6% and 55%. Preoperative diagnosis depends on a combination of clinical features, tumor markers, computed tomography (CT), magnetic resonance imaging, endoscopic ultrasound with cyst fluid analysis, and positron emission tomography-CT. Surgery is indicated for all MCNs.

Original languageEnglish
Pages (from-to)5682-5692
Number of pages11
JournalWorld Journal of Gastroenterology
Issue number45
Publication statusPublished - Dec 2010


  • Pancreatic cystic lesion
  • Pancreatic cystic neoplasm
  • Pancreatic mucin-producing cysts
  • Pancreatic mucinous cystic neoplasm
  • Pancreatic ovarian-type stroma

ASJC Scopus subject areas

  • Gastroenterology


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