Management of multifocal/multicentric breast cancer: Current perspective

Amelia Milulescu, Luigi Di Marino, Nickolas Peradze, Antonio Toesca

Research output: Contribution to journalArticlepeer-review


The incidence of multifocal (MF) and multicentric (MC) breast cancer has a wide variation among different clinical studies, mostly due to the lack of a standardized classification and definition of these two separate entities. The optimal surgical treatment for multiple ipsilateral breast cancer remains a long debated subject. Multifocal and multicentric breast cancer is usually considered a relative contraindication for breast conserving therapy (BCT). In this narrative review we analyzed differences between MC and MF early breast cancer, the role of magnetic resonance imaging (MRI) in detection of multiple breast lesions, and its role in the surgical approach. We evaluate data from the litera-ture about feasibility of breast conservative surgery and loco-regional treatment modalities. Recent studies brought evidence that treatment of patients with MC/MF breast cancer with BCT plus radiotherapy and adjuvant systemic therapy can have low-rates for in-breast recurrence. Prospective studies are needed to confirm these findings.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalChirurgia (Romania)
Issue number1
Publication statusPublished - Jan 1 2017


  • Breast
  • Breast conservative surgery
  • Breast reconstruction
  • Cancer
  • Mastectomy
  • Multicentric breast cancer
  • Multifocal breast cancer
  • Nipple-sparing mastectomy

ASJC Scopus subject areas

  • Surgery


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