Management of neurotrophic keratopathy

Alessandro Lambiase, Paolo Rama, Luigi Aloe, Stefano Bonini

Research output: Contribution to journalArticlepeer-review


Neurotrophic keratopathy is a degenerative corneal disease caused by an impairment of corneal sensitivity. Lack of the sensory nerve's trophic effect is responsible for the impairment in corneal healing and for the changes on the ocular surface that lead to corneal epithelial deficit, ulcer, and perforation. The etiology and recent advances in understanding of the pathogenetic mechanisms of neurotrophic keratopathy are reviewed here. An accurate history and a clinical examination that covers the function of cranial nerves often identify the cause of the disease. Clinical features and guidelines for the differential diagnosis and treatment are presented. Specific medical and surgical treatments, selected on the basis of clinical staging of the disease, can often halt disease progression. Future developments in medical treatment, including the use of neuropeptide and growth factors, are discussed. The identification of corneal anesthesia associated with an epithelial defect allows appropriate treatment and prevention of progression to stromal lysis and perforation. (C) 1999 Lippincott Williams and Wilkins, Inc.

Original languageEnglish
Pages (from-to)270-276
Number of pages7
JournalCurrent Opinion in Ophthalmology
Issue number4
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Ophthalmology


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