Management of nodular sclerosis hodgkin’s disease stage I, II A and B: Evidence for a beneficial effect of MOPP on the relapse rate

Francesco Lauria, Michele Baccarani, Lucio Babini, Ermanno Emiliani, Mauro Fiacchini, Marco Gobbi, Patrizio Mazza, Ruggero Sciascia, Sante Tura

Research output: Contribution to journalArticlepeer-review

Abstract

85 patients with previously untreated Hodgkin’s disease with stage I, II A and B nodular sclerosis were treated. 31 of them with stage I and II A were submitted to radiotherapy alone. All are alive, but 9 of them (30%) relapsed. On the contrary, 35 patients with stage I and II A, and 19 with stage I, II and IIK B were submitted to radiotherapy followed by three courses of MOPP. All 54 patients are alive and relapse-free. No severe complication related to chemotherapy was observed. The analysis of results suggests that 3 courses of MOPP can significantly (p <0.00025) reduce the relapse rate in patients with stage I and II nodular sclerosis, eligible for radiotherapy, without increasing morbidity.

Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalActa Haematologica
Volume62
Issue number5-6
DOIs
Publication statusPublished - 1979

Keywords

  • Hodgkin’s disease
  • MOPP chemotherapy
  • Nodular sclerosis
  • Pathologic stage I, II A and B

ASJC Scopus subject areas

  • Hematology

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