Management of ovarian cancer: guidelines of the Italian Medical Oncology Association (AIOM)

Angiolo Gadducci, Giovanni D. Aletti, Fabio Landoni, Roberta Lazzari, Giorgia Mangili, Paola Olivas, Sandro Pignata, Vanda Salutari, Enrico Sartori, Giovanni Scambia, Gian Franco Zannoni, Roberto Sabbatini, Domenica Lorusso

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Ovarian cancer is the most lethal gynecologic malignancy. Over 5200 new cases of this tumor are diagnosed yearly in Italy, resulting in more than 3600 deaths. In terms of molecular biology, five different ovarian cancer subtypes should be distinguished. Method: This article summarizes the evidence-based guidelines that the Italian Medical Oncology Association (AIOM) has developed with a multidisciplinary panel of experts, including pathologists, gynecologic oncologists, medical oncologists, and radiotherapists, with the support of methodologists, to help clinicians involved in the management of patients with ovarian cancer in their daily clinical practice. Results: The most relevant randomized clinical trials regarding surgery, chemotherapy, and molecularly targeted agents (bevacizumab and PARP inhibitors) in early, advanced, and recurrent disease have been critically analyzed. The levels of evidence and strength of recommendation have been reported for any issue. Conclusion: Women with a clinical suspicion of ovarian cancer should be centralized in referral centers. The BRCA test should be requested for all women with nonmucinous and nonborderline tumors, regardless of age and family history. BRCA testing could be preferentially performed on neoplastic tissue. In the presence of a positive tumor test, a genetic test should always be performed on a blood sample to differentiate between germline mutations, which require counseling and genetic testing of family members, and somatic mutations.

Original languageEnglish
Pages (from-to)100-109
Number of pages10
JournalTumori
Volume107
Issue number2
DOIs
Publication statusPublished - Apr 2021

Keywords

  • Epidemiology and prevention
  • guidelines
  • gynecologic oncology
  • molecular oncology
  • ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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