Abstract
Design: To investigate the frequency, treatment and clinical behaviour of differentiated microcarcinoma of the thyroid gland (PTMC). Patients and methods: Out of 376 patients submitted to surgical treatment for differentiated thyroid cancer from June 1980 to October 2003, 77 had been identified has having a PTMC (63 females, 14 males; mean age 43±13 years). Sixty-seven patients (87%) met the AMES risk definition for low (group I) and 10 (13%) for high-risk (group II) definition. The surgical procedures were lobo-isthmusectomy (n=14) or subtotal thyroidectomy (n=20) and total thyroidectomy (n=43) with node dissection in 15 cases. Follow-up ranging from 9 to 274 months (mean 124±84). Results: Overall patient survival rates were 100 and 94 % at 20 years in groups I and II, respectively (p=ns). There were no significant differences in surgical complications and in survival in patients submitted to total thyroidectomy when compared to partial thyroid resection. The presence of cervical node metastasis did not affect patient survival (p=0.8). The overall mean survival time was 266 months. Conclusions: Despite the overall excellent prognosis, PTMC was associat ed with a 1% disease-related mortality, a 2.5% local recurrence rate, 1% lymph-node recurrence rate, and 1% distant metastasis rate. We recommend total thyroidectomy accompanied by modified neck dissection if enlarged nodes are diagnosed.
| Original language | English |
|---|---|
| Pages (from-to) | 1104-1106 |
| Number of pages | 3 |
| Journal | European Journal of Surgical Oncology |
| Volume | 30 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Dec 2004 |
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Keywords
- Differentiated thyroid cancer
- Microcarcinoma
- Thyroid resections
- Total thyroidectomy
ASJC Scopus subject areas
- Oncology
- Surgery
Cite this
Management of papillary microcarcinoma of the thyroid gland. / Orsenigo, Elena; Beretta, E.; Fiacco, E.; Scaltrini, F.; Veronesi, P.; Invernizzi, L.; Gini, P.; Fiorina, P.; Di Carlo, V.
In: European Journal of Surgical Oncology, Vol. 30, No. 10, 12.2004, p. 1104-1106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Management of papillary microcarcinoma of the thyroid gland
AU - Orsenigo, Elena
AU - Beretta, E.
AU - Fiacco, E.
AU - Scaltrini, F.
AU - Veronesi, P.
AU - Invernizzi, L.
AU - Gini, P.
AU - Fiorina, P.
AU - Di Carlo, V.
PY - 2004/12
Y1 - 2004/12
N2 - Design: To investigate the frequency, treatment and clinical behaviour of differentiated microcarcinoma of the thyroid gland (PTMC). Patients and methods: Out of 376 patients submitted to surgical treatment for differentiated thyroid cancer from June 1980 to October 2003, 77 had been identified has having a PTMC (63 females, 14 males; mean age 43±13 years). Sixty-seven patients (87%) met the AMES risk definition for low (group I) and 10 (13%) for high-risk (group II) definition. The surgical procedures were lobo-isthmusectomy (n=14) or subtotal thyroidectomy (n=20) and total thyroidectomy (n=43) with node dissection in 15 cases. Follow-up ranging from 9 to 274 months (mean 124±84). Results: Overall patient survival rates were 100 and 94 % at 20 years in groups I and II, respectively (p=ns). There were no significant differences in surgical complications and in survival in patients submitted to total thyroidectomy when compared to partial thyroid resection. The presence of cervical node metastasis did not affect patient survival (p=0.8). The overall mean survival time was 266 months. Conclusions: Despite the overall excellent prognosis, PTMC was associat ed with a 1% disease-related mortality, a 2.5% local recurrence rate, 1% lymph-node recurrence rate, and 1% distant metastasis rate. We recommend total thyroidectomy accompanied by modified neck dissection if enlarged nodes are diagnosed.
AB - Design: To investigate the frequency, treatment and clinical behaviour of differentiated microcarcinoma of the thyroid gland (PTMC). Patients and methods: Out of 376 patients submitted to surgical treatment for differentiated thyroid cancer from June 1980 to October 2003, 77 had been identified has having a PTMC (63 females, 14 males; mean age 43±13 years). Sixty-seven patients (87%) met the AMES risk definition for low (group I) and 10 (13%) for high-risk (group II) definition. The surgical procedures were lobo-isthmusectomy (n=14) or subtotal thyroidectomy (n=20) and total thyroidectomy (n=43) with node dissection in 15 cases. Follow-up ranging from 9 to 274 months (mean 124±84). Results: Overall patient survival rates were 100 and 94 % at 20 years in groups I and II, respectively (p=ns). There were no significant differences in surgical complications and in survival in patients submitted to total thyroidectomy when compared to partial thyroid resection. The presence of cervical node metastasis did not affect patient survival (p=0.8). The overall mean survival time was 266 months. Conclusions: Despite the overall excellent prognosis, PTMC was associat ed with a 1% disease-related mortality, a 2.5% local recurrence rate, 1% lymph-node recurrence rate, and 1% distant metastasis rate. We recommend total thyroidectomy accompanied by modified neck dissection if enlarged nodes are diagnosed.
KW - Differentiated thyroid cancer
KW - Microcarcinoma
KW - Thyroid resections
KW - Total thyroidectomy
UR - http://www.scopus.com/inward/record.url?scp=13944282324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13944282324&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2004.07.021
DO - 10.1016/j.ejso.2004.07.021
M3 - Article
C2 - 15522558
AN - SCOPUS:13944282324
VL - 30
SP - 1104
EP - 1106
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
SN - 0748-7983
IS - 10
ER -