Management of primary sarcomas of the retroperitoneum

C. R. Rossi, D. Nitti, M. Foletto, S. Alessio, A. Seno, G. Segato, G. Mancino, F. De Marchi, V. Ninfo, M. Lise

Research output: Contribution to journalArticle

Abstract

We here report on our 10-year experience of surgery in 25 patients with primary retroperitoneal sarcoma and make an appraisal of the more effective available clinical approach. Ten patients had leiomyosarcoma, eight liposarcoma, and seven had other tumor types. Histological grading was G1 in seven patients, G2 in six patients and G3 in 12. Ten patients (40%) underwent wide tumor excision, five (20%) marginal excision, four (16%) partial excision and six (24%) wedge biopsy at laparotomy. Adjacent organ resection was required in 10 of the 15 patients who underwent wide or marginal resection, seven of whom had adjuvant chemo-radiotherapy. After wide resection, local recurrences were observed in 2/10 patients; the 10-year survival rate was 33%. Three out of five patients who underwent marginal resection had local recurrences; one is alive 10 years after surgery and chemo-radiotherapy. Histological grading was the most important prognostic factor. Radical resection is the only available treatment for retroperitoneal sarcomas, and patients with low-grade tumors benefit most from it with respect to survival and local recurrence rate. The efficacy of adjuvant treatment has yet to be clarified.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume19
Issue number4
Publication statusPublished - 1993

Keywords

  • Primary sarcoma
  • Retroperitoneum

ASJC Scopus subject areas

  • Oncology
  • Surgery

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    Rossi, C. R., Nitti, D., Foletto, M., Alessio, S., Seno, A., Segato, G., Mancino, G., De Marchi, F., Ninfo, V., & Lise, M. (1993). Management of primary sarcomas of the retroperitoneum. European Journal of Surgical Oncology, 19(4), 355-360.