Abstract
Constitutional delay of growth and puberty (CDGP) is the most common presenting form of short stature, but no single test can infallibly discriminate CDGP and isolated hypogonadotrophic hypogonadism. Management of puberty in CDGP aims to optimise not only growth - maintaining body proportions and improving peak bone mass without impairing growth potential - but also well-being; for example, the distress boys often suffer because of their lack of growth and pubertal progression can affect their school performance and social relationships. Typical sex steroid treatments to induce puberty in boys with CDGP include testosterone (T) enanthate, T undecanoate, mixed T esters, T transdermal patches, and oxandrolone p.o. Compared with other regimens, short-course low-dose depot T i.m. is an effective, practical, safe, well tolerated, and inexpensive regimen. Some unresolved problems in management include optimal timing and dose of sex steroid treatment, the role of GH in CDGP, and the management of CDGP in girls.
| Original language | English |
|---|---|
| Pages (from-to) | 953-957 |
| Number of pages | 5 |
| Journal | Journal of Pediatric Endocrinology and Metabolism |
| Volume | 14 |
| Issue number | SUPPL. 2 |
| Publication status | Published - 2001 |
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Keywords
- Consensus guidelines
- Constitutional delay of growth and puberty
- Gonadotrophin
- Growth
- Puberty
- Sex steroid treatment
- Testosterone
ASJC Scopus subject areas
- Endocrinology
- Pediatrics, Perinatology, and Child Health
Cite this
Management of puberty in constitutional delay of growth and puberty. / De Luca, F.; Argente, J.; Cavallo, L.; Crowne, E.; Delemarre-Van de Waal, H. A.; De Sanctis, C.; Di Maio, S.; Norjavaara, E.; Oostdijk, W.; Severi, F.; Tonini, G.; Trifirò, G.; Voorhoeve, P. G.; Wu, F.
In: Journal of Pediatric Endocrinology and Metabolism, Vol. 14, No. SUPPL. 2, 2001, p. 953-957.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Management of puberty in constitutional delay of growth and puberty
AU - De Luca, F.
AU - Argente, J.
AU - Cavallo, L.
AU - Crowne, E.
AU - Delemarre-Van de Waal, H. A.
AU - De Sanctis, C.
AU - Di Maio, S.
AU - Norjavaara, E.
AU - Oostdijk, W.
AU - Severi, F.
AU - Tonini, G.
AU - Trifirò, G.
AU - Voorhoeve, P. G.
AU - Wu, F.
PY - 2001
Y1 - 2001
N2 - Constitutional delay of growth and puberty (CDGP) is the most common presenting form of short stature, but no single test can infallibly discriminate CDGP and isolated hypogonadotrophic hypogonadism. Management of puberty in CDGP aims to optimise not only growth - maintaining body proportions and improving peak bone mass without impairing growth potential - but also well-being; for example, the distress boys often suffer because of their lack of growth and pubertal progression can affect their school performance and social relationships. Typical sex steroid treatments to induce puberty in boys with CDGP include testosterone (T) enanthate, T undecanoate, mixed T esters, T transdermal patches, and oxandrolone p.o. Compared with other regimens, short-course low-dose depot T i.m. is an effective, practical, safe, well tolerated, and inexpensive regimen. Some unresolved problems in management include optimal timing and dose of sex steroid treatment, the role of GH in CDGP, and the management of CDGP in girls.
AB - Constitutional delay of growth and puberty (CDGP) is the most common presenting form of short stature, but no single test can infallibly discriminate CDGP and isolated hypogonadotrophic hypogonadism. Management of puberty in CDGP aims to optimise not only growth - maintaining body proportions and improving peak bone mass without impairing growth potential - but also well-being; for example, the distress boys often suffer because of their lack of growth and pubertal progression can affect their school performance and social relationships. Typical sex steroid treatments to induce puberty in boys with CDGP include testosterone (T) enanthate, T undecanoate, mixed T esters, T transdermal patches, and oxandrolone p.o. Compared with other regimens, short-course low-dose depot T i.m. is an effective, practical, safe, well tolerated, and inexpensive regimen. Some unresolved problems in management include optimal timing and dose of sex steroid treatment, the role of GH in CDGP, and the management of CDGP in girls.
KW - Consensus guidelines
KW - Constitutional delay of growth and puberty
KW - Gonadotrophin
KW - Growth
KW - Puberty
KW - Sex steroid treatment
KW - Testosterone
UR - http://www.scopus.com/inward/record.url?scp=0034890413&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034890413&partnerID=8YFLogxK
M3 - Article
C2 - 11529401
AN - SCOPUS:0034890413
VL - 14
SP - 953
EP - 957
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
SN - 0334-018X
IS - SUPPL. 2
ER -