Management of staphylococcal endocarditis in drug addicts. Combined therapy with oral rifampicin and aminoglycosides

F. Suter, R. Maserati, G. Carnevale, P. Marone, C. Filice, E. Concia

Research output: Contribution to journalArticle

Abstract

Staphylococcal endocarditis is a condition affecting intravenous drug abusers at increasing rates, and its treatment is still controversial. We used, successfully, high doses of rifampicin, associated with an aminoglycoside, for the treatment of 2 heroin addicts. In the first, we found a left-sided endocarditis with metastatic abscesses in brain, both kidneys, liver and spleen; in the other, the finding of bilateral lung abscesses was related to embolic episodes from a diseased tricuspid valve. Since the isolated strains of Staphylococcus aureus were tolerant to methicillin, we used oral rifampicin (20 mg/kg/day) plus an aminoglycoside (amikacin in the former and gentamicin in the latter), after in-vitro testing had proved these combinations to be effective. We achieved, in both cases, stable bactericidal concentrations in the serum and a lasting clinical recovery.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume13
Issue numberSUPPL. C
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology

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