Staphylococcal endocarditis is a condition affecting intravenous drug abusers at increasing rates, and its treatment is still controversial. We used, successfully, high doses of rifampicin, associated with an aminoglycoside, for the treatment of 2 heroin addicts. In the first, we found a left-sided endocarditis with metastatic abscesses in brain, both kidneys, liver and spleen; in the other, the finding of bilateral lung abscesses was related to embolic episodes from a diseased tricuspid valve. Since the isolated strains of Staphylococcus aureus were tolerant to methicillin, we used oral rifampicin (20 mg/kg/day) plus an aminoglycoside (amikacin in the former and gentamicin in the latter), after in-vitro testing had proved these combinations to be effective. We achieved, in both cases, stable bactericidal concentrations in the serum and a lasting clinical recovery.
|Number of pages||4|
|Journal||Journal of Antimicrobial Chemotherapy|
|Issue number||SUPPL. C|
|Publication status||Published - 1984|
ASJC Scopus subject areas