TY - JOUR
T1 - Management of targeted therapies in cancer patients with chronic kidney disease, or on haemodialysis
T2 - An Associazione Italiana di Oncologia Medica (AIOM)/Societa’ Italiana di Nefrologia (SIN) multidisciplinary consensus position paper
AU - Silvestris, Nicola
AU - Argentiero, Antonella
AU - Cosmai, Laura
AU - Porta, Camillo
AU - Gesualdo, Loreto
AU - Brunori, Giuliano
AU - Brunetti, Oronzo
AU - Rampino, Teresa
AU - Secondino, Simona
AU - Rizzo, Gianpiero
AU - Pedrazzoli, Paolo
PY - 2019/8/1
Y1 - 2019/8/1
N2 - The increasing availability of novel biological anticancer agents has greatly improved the outcome of several cancer patients; unfortunately, data regarding efficacy, safety and pharmacokinetics of many of these agents in patients with chronic renal disease or on hemodialysis are scanty. Furthermore these results are controversial and a treatment strategy has not yet been established. Therefore, the Associazione Italiana di Oncologia Medica and the Società italiana di Nefrologia undertook the present work aiming at providing health professionals with a tool for easier clinical management of target therapies in this setting of patients. A web-based search of MEDLINE/PubMed library data published from 2000 to June 2018 has been performed. More than one hundred papers, including recommendations and expert opinions, were selected and discussed by the authors. A panel of experts provided additional biological and clinical information, helping in clarifying some issues in the absence of clear-cut information from the literature.
AB - The increasing availability of novel biological anticancer agents has greatly improved the outcome of several cancer patients; unfortunately, data regarding efficacy, safety and pharmacokinetics of many of these agents in patients with chronic renal disease or on hemodialysis are scanty. Furthermore these results are controversial and a treatment strategy has not yet been established. Therefore, the Associazione Italiana di Oncologia Medica and the Società italiana di Nefrologia undertook the present work aiming at providing health professionals with a tool for easier clinical management of target therapies in this setting of patients. A web-based search of MEDLINE/PubMed library data published from 2000 to June 2018 has been performed. More than one hundred papers, including recommendations and expert opinions, were selected and discussed by the authors. A panel of experts provided additional biological and clinical information, helping in clarifying some issues in the absence of clear-cut information from the literature.
KW - Cancer
KW - Chronic kidney disease
KW - End-stage renal disease
KW - ESRD
KW - Hemodialysis
KW - Kidney failure
KW - Renal impairment
KW - Targeted therapy
UR - http://www.scopus.com/inward/record.url?scp=85066622371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066622371&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2019.05.016
DO - 10.1016/j.critrevonc.2019.05.016
M3 - Review article
AN - SCOPUS:85066622371
VL - 140
SP - 39
EP - 51
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
SN - 1040-8428
ER -