Management of the elderly cancer patients complexity: The radiation oncology potential

Giuseppe Colloca, Luca Tagliaferri, Beatrice Di Capua, Maria Antonietta Gambacorta, Vito Lanzotti, Andrea Bellieni, Silvio Monfardini, Lodovico Balducci, Roberto Bernabei, William C. Cho, Vincenzo Valentini

Research output: Contribution to journalReview articlepeer-review


Radiation oncology has the potential to be an excellent option for the frail elderly cancer patients because of its limited systemic toxicities. It can be effective for curative, prophylactic, disease control or palliative purposes. Currently about 60% of all cancer patients undergoing active treatment at some point receive radiation treatment. However, though widely used, there are limited clinical trials strictly designed for the elderly. This paper will review the key points in the assessment and treatment of elderly cancer patient including quality of life, active life expectancy, cognitive performance, frailty, sarcopenia and how the new technologies can help to reach the key goal of maintaining autonomy and independence for the elderly cancer patient.

Original languageEnglish
Pages (from-to)649-657
Number of pages9
JournalAging and Disease
Issue number3
Publication statusPublished - May 1 2020


  • Cancer
  • Complexity
  • Elderly
  • Frailty
  • Personalized treatment
  • Quality of life
  • Radiation oncology
  • Sarcopenia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cell Biology


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