Management of the patient with medically refractory epilepsy

Tiziana Granata, Nicola Marchi, Erin Carlton, Chaitali Ghosh, Jorge Gonzalez-Martinez, Andreas V. Alexopoulos, Damir Janigro

Research output: Contribution to journalArticle

Abstract

Epilepsy imposes a significant clinical, epidemiologic and economic burden on societies throughout the world. Despite the development of more than ten new antiepileptic drugs over the past 15 years, approximately a third of patients with epilepsy remain resistant to pharmacotherapy. Individuals who fail to respond, or respond only partially, continue to have incapacitating seizures. Managing patients with medically refractory epilepsy is challenging and requires a structured multidisciplinary approach in specialized clinics. If the problems related to drug resistance could be resolved, even in part, by improving the pharmacokinetic profile of existing drugs, the economic savings would be remarkable and the time required to design drugs that achieve seizure control would be shorter than the discovery of new targets and molecules was required. A promising approach is the use of corticosteroids that may have a dual beneficial effect. Resective brain surgery remains the ultimate and highly successful approach to multiple drug resistance in epileptic patients.

Original languageEnglish
Pages (from-to)1791-1802
Number of pages12
JournalExpert Review of Neurotherapeutics
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Epilepsy
Seizures
Economics
Drug Design
Multiple Drug Resistance
Drug Resistance
Anticonvulsants
Adrenal Cortex Hormones
Pharmacokinetics
Drug Therapy
Brain
Pharmaceutical Preparations

Keywords

  • Combination therapy steroids
  • Dexamethasone
  • Epileptic seizures
  • Multiple drug resistance
  • Neurological surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology (medical)

Cite this

Granata, T., Marchi, N., Carlton, E., Ghosh, C., Gonzalez-Martinez, J., Alexopoulos, A. V., & Janigro, D. (2009). Management of the patient with medically refractory epilepsy. Expert Review of Neurotherapeutics, 9(12), 1791-1802. https://doi.org/10.1586/ern.09.114

Management of the patient with medically refractory epilepsy. / Granata, Tiziana; Marchi, Nicola; Carlton, Erin; Ghosh, Chaitali; Gonzalez-Martinez, Jorge; Alexopoulos, Andreas V.; Janigro, Damir.

In: Expert Review of Neurotherapeutics, Vol. 9, No. 12, 12.2009, p. 1791-1802.

Research output: Contribution to journalArticle

Granata, T, Marchi, N, Carlton, E, Ghosh, C, Gonzalez-Martinez, J, Alexopoulos, AV & Janigro, D 2009, 'Management of the patient with medically refractory epilepsy', Expert Review of Neurotherapeutics, vol. 9, no. 12, pp. 1791-1802. https://doi.org/10.1586/ern.09.114
Granata T, Marchi N, Carlton E, Ghosh C, Gonzalez-Martinez J, Alexopoulos AV et al. Management of the patient with medically refractory epilepsy. Expert Review of Neurotherapeutics. 2009 Dec;9(12):1791-1802. https://doi.org/10.1586/ern.09.114
Granata, Tiziana ; Marchi, Nicola ; Carlton, Erin ; Ghosh, Chaitali ; Gonzalez-Martinez, Jorge ; Alexopoulos, Andreas V. ; Janigro, Damir. / Management of the patient with medically refractory epilepsy. In: Expert Review of Neurotherapeutics. 2009 ; Vol. 9, No. 12. pp. 1791-1802.
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