Management of therapy-resistant reflex seizures

U. Aguglia, P. Tinuper, P. Santanelli, A. Quattrone, H. Gastaut

Research output: Chapter in Book/Report/Conference proceedingChapter


Long-term (mean 4 years) treatment with clobazam (CLB), as adjunct medication, was performed in 8 epileptic patients presenting with startle-induced seizures (SIS: 6 patients) or eating seizures (ES: 2 patients), two kinds of therapy-resistant reflex fits. Continuous (0.5 - 1.3 mg/kg/day, three times daily, orally) long-term CLB-prophylaxis of SIS induced complete or partial control of the reflex fits in 66.6% and 33.3% of patients respectively. Intermittent (10 mg 1 hour before meals, orally) long-term CLB-prophylaxis of Es reduced considerably the seizure frequency in 2 ES-patients. Long term CLB-prophylaxis may be useful in the management of patients with therapy-resistant reflex seizures.

Original languageEnglish
Title of host publicationBollettino - Lega Italiana contro l'Epilessia
Number of pages2
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Neurology


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