Management to optimize organ procurement in brain dead donors

L. Mascia, I. Mastromauro, S. Viberti, M. Vincenzi, M. Zanello

Research output: Contribution to journalArticle

Abstract

The demand for donor organs continues to exceed the number of organs available for transplantation. Many reasons may account for this discrepancy, such as the lack of consent, the absence of an experienced coordinator team able to solve logistical problems, the use of strict donor criteria, and suboptimal, unstandardized critical care management of potential organ donors. This has resulted in efforts to improve the medical care delivered to potential organ donors, so as to reduce organ shortages, improve organ procurement, and promote graft survival. The physiological changes that follow brain death entail a high incidence of complications jeopardizing potentially transplantable organs. Adverse events include cardiovascular changes, endocrine and metabolic disturbances, and disruption of internal homeostasis. Brain death also upregulates the release of pro-inflammatory molecules. Recent findings support the hypothesis that a preclinical lung injury characterized by an enhanced inflammatory response is present in potential donors and may predispose recipients to an adverse clinical prognosis following lung transplantation. In clinical practice, hypotension, diabetes insipidus, relative hypothermia, and natremia are more common than disseminated intravascular coagulation, cardiac arrhythmias, pulmonary oedema, acute lung injury, and metabolic acidosis. Strategies for the management of organ donors exist and consist of the notmalization of donor physiology. Management has been complicated by the recent use of "marginal" donors and donors of advanced age or with "extended" criteria. Current guidelines suggest that the priority of critical care management for potential organ donors should be shifted from a "cerebral protective" strategy to a multimodal strategy aimed to preserve peripheral organ function.

Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalMinerva Anestesiologica
Volume75
Issue number3
Publication statusPublished - Mar 2009

Fingerprint

Tissue and Organ Procurement
Brain Death
Tissue Donors
Critical Care
Diabetes Insipidus
Lung Transplantation
Acute Lung Injury
Disseminated Intravascular Coagulation
Lung Injury
Organ Transplantation
Graft Survival
Pulmonary Edema
Acidosis
Hypothermia
Hypotension
Cardiac Arrhythmias
Homeostasis
Up-Regulation
Guidelines

Keywords

  • Brain death
  • Tissue and organ procurement
  • Tissue donors

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Mascia, L., Mastromauro, I., Viberti, S., Vincenzi, M., & Zanello, M. (2009). Management to optimize organ procurement in brain dead donors. Minerva Anestesiologica, 75(3), 125-133.

Management to optimize organ procurement in brain dead donors. / Mascia, L.; Mastromauro, I.; Viberti, S.; Vincenzi, M.; Zanello, M.

In: Minerva Anestesiologica, Vol. 75, No. 3, 03.2009, p. 125-133.

Research output: Contribution to journalArticle

Mascia, L, Mastromauro, I, Viberti, S, Vincenzi, M & Zanello, M 2009, 'Management to optimize organ procurement in brain dead donors', Minerva Anestesiologica, vol. 75, no. 3, pp. 125-133.
Mascia L, Mastromauro I, Viberti S, Vincenzi M, Zanello M. Management to optimize organ procurement in brain dead donors. Minerva Anestesiologica. 2009 Mar;75(3):125-133.
Mascia, L. ; Mastromauro, I. ; Viberti, S. ; Vincenzi, M. ; Zanello, M. / Management to optimize organ procurement in brain dead donors. In: Minerva Anestesiologica. 2009 ; Vol. 75, No. 3. pp. 125-133.
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