Managing lipid metabolism in proliferating cells: New perspective for metformin usage in cancer therapy

Daniele Lettieri Barbato, Rolando Vegliante, Enrico Desideri, Maria Rosa Ciriolo

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer cells metabolically adapt to undergo cellular proliferation. Lipids, besides their well-known role as energy storage, represent the major building blocks for the synthesis of neo-generated membranes. There is increasing evidence that cancer cells show specific alterations in different aspects of lipid metabolism. The changes of expression and activity of lipid metabolising enzymes are directly regulated by the activity of oncogenic signals. The dependence of tumour cells on the deregulated lipid metabolism suggests that proteins involved in this process could be excellent chemotherapeutic targets for cancer treatment. Due to its rare side effects in non-cancerous cells, metformin has been recently revaluated as a potential anti-tumourigenic drug, which negatively affects lipid biosynthetic pathways. In this review we summarised the emerging molecular events linking the anti-proliferative effect of metformin with lipid metabolism in cancer cells.

Original languageEnglish
Pages (from-to)317-324
Number of pages8
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1845
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • ACC
  • ACLY
  • AMPK
  • ATGL
  • Lipa
  • SREBPs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

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