Managing Ovarian tumors during pregnancy

Robert Fruscio, Lorenzo Ceppi, Giovanni Codacci-Pisanelli, Fedro Alessandro Peccatori

Research output: Chapter in Book/Report/Conference proceedingChapter


Ovarian masses may complicate 2.3-4.1 % [ 1 ] of all pregnancies. Due to the extensive use of transvaginal ultrasound (US) in the fi rst trimester for the assessment of fetal viability, growth, and anomalies, the diagnosis of ovarian masses during pregnancy has increased in the last decades. Most of these are asymptomatic and undergo spontaneous resolution without treatment [ 2 ]. Pain related to mass torsion, enlargement, or rupture occurs in 3-28 % of cases. Most persistent ovarian masses diagnosed during pregnancy are benign tumors, with only 1-3 % [ 3 ] being malignant. After cervical cancer, ovarian cancer (OC) is the second most frequent gynecologic cancer complicating pregnancy, with an incidence rate of 1:12.000-47.000 pregnancies. Updated INCIP (International Network on Cancer, Infertility and Pregnancy) registration study described the frequency of cancer in pregnancy in European countries [ 4 ]: among more than 1000 cases of diagnosed cancer during pregnancy, ovarian cancer accounts for 5 % of all cases. Histological subtypes are similar to those reported for young nonpregnant women. Most common benign tumors are teratomas and serous cystadenomas, whereas most common malignant histology is epithelial invasive and borderline cancer. Eighty percent of malignancies are diagnosed at early stage. Germ cell tumors are less frequent, with few cases reported in several series [ 5 ]. Table 13.1 describes a summary of ovarian cancer cases reported in literature so far.

Original languageEnglish
Title of host publicationManaging Cancer During Pregnancy
PublisherSpringer International Publishing
Number of pages10
ISBN (Electronic)9783319288000
ISBN (Print)9783319287980
Publication statusPublished - Jan 1 2016

ASJC Scopus subject areas

  • Medicine(all)


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