Manic/hypomanic symptoms and quality of life measures in patients with epilepsy

Marco Mula, Regina Jauch, Andrea Cavanna, Laura Collimedaglia, Davide Barbagli, Verena Gaus, Rebekka Kretz, Michele Viana, Roberto Cantello, Francesco Monaco, Bettina Schmitz

Research output: Contribution to journalArticlepeer-review


Purpose: Although several studies pointed out an association between depression and quality of life (QoL) of patients with epilepsy, data about manic/hypomanic symptoms (MHS) remain scanty. In this study, we sought to investigate their relationship with social and health-related QoL measures in patients with epilepsy. Methods: Consecutive adult outpatients with epilepsy were assessed using the M.I.N.I. Plus version 5.0.0 and the QOLIE-31. Results: Among 117 evaluated patients, 17 fulfilled DSM-IV criteria for manic/hypomanic episodes. Patients with MHS, as compared to those without, showed lower scores in emotional well-being, energy and fatigue, medication effects, social function and total QOLIE score. However, there was no between-groups difference in educational achievements, employment status, living situation, comorbid psychiatric disorders, history of suicide or abuse of illicit drugs. Conclusions: MHS are associated with poor QoL measures in patients with epilepsy, though without differences in educational achievements, employment status and independent living.

Original languageEnglish
Pages (from-to)530-532
Number of pages3
Issue number7
Publication statusPublished - Sep 2009


  • Bipolar disorder
  • Epilepsy
  • Hypomania
  • Mania
  • Quality of life

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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