Manipulating dendritic cells to induce regulatory T cells

G. Penna, N. Giarratana, S. Amuchastegui, R. Mariani, K. C. Daniel, L. Adorini

Research output: Contribution to journalArticlepeer-review

Abstract

Dendritic cells (DCs) induce and regulate T-cell responses, and tolerogenic DCs can promote the development of regulatory T cells with suppressive activity. The possibility of manipulating DCs using different pharmacological or biological agents, enabling them to exert tolerogenic activities, could be exploited to better control a variety of chronic inflammatory conditions, from autoimmune diseases to allograft rejection.

Original languageEnglish
Pages (from-to)1033-1039
Number of pages7
JournalMicrobes and Infection
Volume7
Issue number7-8
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Allograft rejection
  • Anti-inflammatory drugs
  • Autoimmune diseases
  • Calcitriol
  • Immunomodulation
  • Immunosuppressive agents
  • Tolerogenic dendritic cells
  • VDR agonist
  • Vitamin D receptor

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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