Manipulating dendritic cells to induce regulatory T cells

G. Penna; N. Giarratana; S. Amuchastegui; R. Mariani; K. C. Daniel; L. Adorini

doi:10.1016/j.micinf.2005.03.025

Manipulating dendritic cells to induce regulatory T cells

G. Penna, N. Giarratana, S. Amuchastegui, R. Mariani, K. C. Daniel, L. Adorini

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Dendritic cells (DCs) induce and regulate T-cell responses, and tolerogenic DCs can promote the development of regulatory T cells with suppressive activity. The possibility of manipulating DCs using different pharmacological or biological agents, enabling them to exert tolerogenic activities, could be exploited to better control a variety of chronic inflammatory conditions, from autoimmune diseases to allograft rejection.

Original language	English
Pages (from-to)	1033-1039
Number of pages	7
Journal	Microbes and Infection
Volume	7
Issue number	7-8
DOIs	https://doi.org/10.1016/j.micinf.2005.03.025
Publication status	Published - Jun 2005

Keywords

Allograft rejection
Anti-inflammatory drugs
Autoimmune diseases
Calcitriol
Immunomodulation
Immunosuppressive agents
Tolerogenic dendritic cells
VDR agonist
Vitamin D receptor

ASJC Scopus subject areas

Microbiology
Infectious Diseases

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title = "Manipulating dendritic cells to induce regulatory T cells",

abstract = "Dendritic cells (DCs) induce and regulate T-cell responses, and tolerogenic DCs can promote the development of regulatory T cells with suppressive activity. The possibility of manipulating DCs using different pharmacological or biological agents, enabling them to exert tolerogenic activities, could be exploited to better control a variety of chronic inflammatory conditions, from autoimmune diseases to allograft rejection.",

keywords = "Allograft rejection, Anti-inflammatory drugs, Autoimmune diseases, Calcitriol, Immunomodulation, Immunosuppressive agents, Tolerogenic dendritic cells, VDR agonist, Vitamin D receptor",

author = "G. Penna and N. Giarratana and S. Amuchastegui and R. Mariani and Daniel, {K. C.} and L. Adorini",

year = "2005",

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AU - Penna, G.

AU - Giarratana, N.

AU - Amuchastegui, S.

AU - Mariani, R.

AU - Daniel, K. C.

AU - Adorini, L.

PY - 2005/6

Y1 - 2005/6

N2 - Dendritic cells (DCs) induce and regulate T-cell responses, and tolerogenic DCs can promote the development of regulatory T cells with suppressive activity. The possibility of manipulating DCs using different pharmacological or biological agents, enabling them to exert tolerogenic activities, could be exploited to better control a variety of chronic inflammatory conditions, from autoimmune diseases to allograft rejection.

AB - Dendritic cells (DCs) induce and regulate T-cell responses, and tolerogenic DCs can promote the development of regulatory T cells with suppressive activity. The possibility of manipulating DCs using different pharmacological or biological agents, enabling them to exert tolerogenic activities, could be exploited to better control a variety of chronic inflammatory conditions, from autoimmune diseases to allograft rejection.

KW - Allograft rejection

KW - Anti-inflammatory drugs

KW - Autoimmune diseases

KW - Calcitriol

KW - Immunomodulation

KW - Immunosuppressive agents

KW - Tolerogenic dendritic cells

KW - VDR agonist

KW - Vitamin D receptor

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