Deficit della lectina legante il mannosio (MBL) nelle infezioni delle vie respiratorie superiori in età pediatrica

Translated title of the contribution: Mannan binding lectin (MBL) deficiency in upper respiratory tract infections of a pediatric population

P. Accardo, S. Napolitano, E. Gucciardino, D. Bellavia

Research output: Contribution to journalArticle

Abstract

Non clonal or innate immune system plays a key role in the immediate response to infections. This is important during the window of vulnerability experienced by all infants following the waning of passive protection prompted by maternal antibodies. The complement system is an intégra I part of the innate immune system. A new C activation pathway is initiated by the binding ofmannan binding lectin (MBL) to carbohydrates. MBL is structurally related to the complement Clq and to collcctins, and seems to activate the C through two associated serine proteases known as M ASP 1 and 2, which arc similar to Clr and Cls of the classical pathway. MBL binds to certain carbohydrate structures of many microorganisms and exhibits antibacterial activity through killing mediated by terminal, lytic complement components or by promoting opsonization and phagocytosis. The plasma concentration of MBL is genetically deter- ' mined, and low serum concentration could be associated with frequent infections in childhood. We now report a significant correlation between the low serum MBL concentration and susceptility to upper respiratory tract infections in a pédiatrie population. 2/29 individuals affected by recurrent tonsillitis vs 11171 controls (p <0,05 by exact Fisher's test) were found with low serum MBL concentration. Moreover 9129patients versus 44/236 controls had C4 nullalleles (p = 0.04 by exact Fisher's test). Primary immunodeficiencies early diagnosis could be important because a prompt treatment of infections helps avoiding complications proving life saving in certain instances. Appreciation of the genetic nature of a host defence defect makes possible family counseling, where indicated and a better understanding of the role of each factor in establishing immune system equilibrium.

Original languageItalian
Pages (from-to)947-953
Number of pages7
JournalRivista Italiana di Pediatria
Volume24
Issue number5
Publication statusPublished - 1998

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Mannose-Binding Lectin
Respiratory Tract Infections
Pediatrics
Population
Immune System
Infection
Serum
Carbohydrates
Tonsillitis
Serine Proteases
Phagocytosis
Counseling
Early Diagnosis
Mothers
Antibodies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Deficit della lectina legante il mannosio (MBL) nelle infezioni delle vie respiratorie superiori in età pediatrica. / Accardo, P.; Napolitano, S.; Gucciardino, E.; Bellavia, D.

In: Rivista Italiana di Pediatria, Vol. 24, No. 5, 1998, p. 947-953.

Research output: Contribution to journalArticle

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