Mannoproteins from Candida albicans elicit a Th-type-1 cytokine profile in human Candida specific long term T cell cultures

A. La Sala, F. Urbani, A. Torosantucci, A. Cassone, C. M. Ausiello

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Abstract

Since T lymphocytes are active producers of regulatory cytokines, long term T cell cultures (LTTC) specific for a major mannoproteic antigen (MP) of Candida albicans from peripheral blood mononuclear cells (PBMC) of healthy donors were generated and their cytokine profile studied. LTTC consisted of an expanded CD3CD4 T-helper (Th) populations, with a high proportion of CD45R0 T memory cells. Stimulation of LTTC by MP induced a Th-1 type cytokine profile, as indicated by the presence of IFN-γ and the absence of IL-5 (both as mRNA and protein) in cell cultures and supernatants. These results suggest a predominant Th1 response elicited by C. albicans mannoprotein antigen in human PBMC.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume10
Issue number1
Publication statusPublished - Jan 1996

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Keywords

  • Candida albicans
  • Cytokines
  • T cell cultures

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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