Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection

Antonio Victor Campos Coelho, Lucas André Cavalcanti Brandão, Rafael Lima Guimarães, Paula Loureiro, José Luiz De Lima Filho, Luiz Cláudio Arraes De Alencar, Sergio Crovella, Ludovica Segat

Research output: Contribution to journalArticlepeer-review

Abstract

Variations in genes involved in the immune response pathways may influence the interaction between viruses (such as Human T-lymphotropic virus, HTLV-1) and the host. The mannose binding lectin (MBL) and its associated serine protease type 2 (MASP-2) promote the activation of the lectin pathway of the complement system. As the interaction of complement system with HTLV-1 is not well understood, the MBL2 promoter/exon 1 polymorphisms and a MASP2 missense polymorphism were examined in a Northeast Brazilian population, looking for a possible relationship between these variations and the susceptibility to HTLV-1 infection. The present study describes an association between a polymorphism in the MASP2 gene and susceptibility to HTLV-1 infection, and provides further evidence of an association between the MBL2 gene and HTLV-1 infection. These findings suggest an important role of the complement system activation, via the lectin pathway, in the susceptibility to HTLV-1 infection.

Original languageEnglish
Pages (from-to)1829-1835
Number of pages7
JournalJournal of Medical Virology
Volume85
Issue number10
DOIs
Publication statusPublished - Oct 2013

Keywords

  • HTLV
  • Innate immunity
  • MASP2
  • MBL2
  • SNPs

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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