TY - JOUR
T1 - Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection
AU - Coelho, Antonio Victor Campos
AU - Brandão, Lucas André Cavalcanti
AU - Guimarães, Rafael Lima
AU - Loureiro, Paula
AU - De Lima Filho, José Luiz
AU - De Alencar, Luiz Cláudio Arraes
AU - Crovella, Sergio
AU - Segat, Ludovica
PY - 2013/10
Y1 - 2013/10
N2 - Variations in genes involved in the immune response pathways may influence the interaction between viruses (such as Human T-lymphotropic virus, HTLV-1) and the host. The mannose binding lectin (MBL) and its associated serine protease type 2 (MASP-2) promote the activation of the lectin pathway of the complement system. As the interaction of complement system with HTLV-1 is not well understood, the MBL2 promoter/exon 1 polymorphisms and a MASP2 missense polymorphism were examined in a Northeast Brazilian population, looking for a possible relationship between these variations and the susceptibility to HTLV-1 infection. The present study describes an association between a polymorphism in the MASP2 gene and susceptibility to HTLV-1 infection, and provides further evidence of an association between the MBL2 gene and HTLV-1 infection. These findings suggest an important role of the complement system activation, via the lectin pathway, in the susceptibility to HTLV-1 infection.
AB - Variations in genes involved in the immune response pathways may influence the interaction between viruses (such as Human T-lymphotropic virus, HTLV-1) and the host. The mannose binding lectin (MBL) and its associated serine protease type 2 (MASP-2) promote the activation of the lectin pathway of the complement system. As the interaction of complement system with HTLV-1 is not well understood, the MBL2 promoter/exon 1 polymorphisms and a MASP2 missense polymorphism were examined in a Northeast Brazilian population, looking for a possible relationship between these variations and the susceptibility to HTLV-1 infection. The present study describes an association between a polymorphism in the MASP2 gene and susceptibility to HTLV-1 infection, and provides further evidence of an association between the MBL2 gene and HTLV-1 infection. These findings suggest an important role of the complement system activation, via the lectin pathway, in the susceptibility to HTLV-1 infection.
KW - HTLV
KW - Innate immunity
KW - MASP2
KW - MBL2
KW - SNPs
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U2 - 10.1002/jmv.23656
DO - 10.1002/jmv.23656
M3 - Article
C2 - 23861212
AN - SCOPUS:84881026199
VL - 85
SP - 1829
EP - 1835
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 10
ER -