Mannose-binding lectin gene (MBL-2) polymorphism in oral lichen planus

Andreza Barkokebas, Alessandra de Albuquerque T. Carvalho, Paulo Roberto Eleutério de Souza, Ricardo Santiago Gomez, Guilherme Machado Xavier, Camila Maria Beder Ribeiro, Sergio Crovella, Stephen Ross Porter, Jair Carneiro Leão

Research output: Contribution to journalArticle

Abstract

TNF-α may be associated with the etiopathogenesis of oral lichen planus (OLP), and it has been suggested that polymorphism of mannose-binding lectin (MBL) increases the in vitro production of TNF- α. The aim of the present study was to assess the relevance of genetic diversity of MBL in OLP. The study sample comprised 90 individuals, 45 OLP patients and 45 healthy volunteers. MBL-2 gene was amplified using real-time PCR. Frequency of A/A genotype was 55. 6% in OLP and 53. 3% in healthy volunteers. Likewise, A/0 heterozygote genotype was found in 42. 2% and 35. 6%; 2. 2% and 11. 1%, had the recessive 0/0 genotype respectively. Frequencies of the "A" and "0" alleles were 77% and 23% in the OLP group and 71. 2% in control group. There were no statistically significant differences regarding genotype frequency (p = 0. 546) or allele frequency (p = 0. 497). In conclusion, no significant association was found between polymorphism of MBL-2 gene and OLP.

Original languageEnglish
Pages (from-to)699-704
Number of pages6
JournalClinical Oral Investigations
Volume15
Issue number5
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Mannose-binding lectin
  • Oral lichen planus
  • Polymorphism

ASJC Scopus subject areas

  • Dentistry(all)

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  • Cite this

    Barkokebas, A., de Albuquerque T. Carvalho, A., de Souza, P. R. E., Gomez, R. S., Xavier, G. M., Ribeiro, C. M. B., Crovella, S., Porter, S. R., & Leão, J. C. (2011). Mannose-binding lectin gene (MBL-2) polymorphism in oral lichen planus. Clinical Oral Investigations, 15(5), 699-704. https://doi.org/10.1007/s00784-010-0428-4