Abstract
TNF-α may be associated with the etiopathogenesis of oral lichen planus (OLP), and it has been suggested that polymorphism of mannose-binding lectin (MBL) increases the in vitro production of TNF- α. The aim of the present study was to assess the relevance of genetic diversity of MBL in OLP. The study sample comprised 90 individuals, 45 OLP patients and 45 healthy volunteers. MBL-2 gene was amplified using real-time PCR. Frequency of A/A genotype was 55. 6% in OLP and 53. 3% in healthy volunteers. Likewise, A/0 heterozygote genotype was found in 42. 2% and 35. 6%; 2. 2% and 11. 1%, had the recessive 0/0 genotype respectively. Frequencies of the "A" and "0" alleles were 77% and 23% in the OLP group and 71. 2% in control group. There were no statistically significant differences regarding genotype frequency (p = 0. 546) or allele frequency (p = 0. 497). In conclusion, no significant association was found between polymorphism of MBL-2 gene and OLP.
| Original language | English |
|---|---|
| Pages (from-to) | 699-704 |
| Number of pages | 6 |
| Journal | Clinical Oral Investigations |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2011 |
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Keywords
- Mannose-binding lectin
- Oral lichen planus
- Polymorphism
ASJC Scopus subject areas
- Dentistry(all)
Cite this
Mannose-binding lectin gene (MBL-2) polymorphism in oral lichen planus. / Barkokebas, Andreza; de Albuquerque T. Carvalho, Alessandra; de Souza, Paulo Roberto Eleutério; Gomez, Ricardo Santiago; Xavier, Guilherme Machado; Ribeiro, Camila Maria Beder; Crovella, Sergio; Porter, Stephen Ross; Leão, Jair Carneiro.
In: Clinical Oral Investigations, Vol. 15, No. 5, 10.2011, p. 699-704.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mannose-binding lectin gene (MBL-2) polymorphism in oral lichen planus
AU - Barkokebas, Andreza
AU - de Albuquerque T. Carvalho, Alessandra
AU - de Souza, Paulo Roberto Eleutério
AU - Gomez, Ricardo Santiago
AU - Xavier, Guilherme Machado
AU - Ribeiro, Camila Maria Beder
AU - Crovella, Sergio
AU - Porter, Stephen Ross
AU - Leão, Jair Carneiro
PY - 2011/10
Y1 - 2011/10
N2 - TNF-α may be associated with the etiopathogenesis of oral lichen planus (OLP), and it has been suggested that polymorphism of mannose-binding lectin (MBL) increases the in vitro production of TNF- α. The aim of the present study was to assess the relevance of genetic diversity of MBL in OLP. The study sample comprised 90 individuals, 45 OLP patients and 45 healthy volunteers. MBL-2 gene was amplified using real-time PCR. Frequency of A/A genotype was 55. 6% in OLP and 53. 3% in healthy volunteers. Likewise, A/0 heterozygote genotype was found in 42. 2% and 35. 6%; 2. 2% and 11. 1%, had the recessive 0/0 genotype respectively. Frequencies of the "A" and "0" alleles were 77% and 23% in the OLP group and 71. 2% in control group. There were no statistically significant differences regarding genotype frequency (p = 0. 546) or allele frequency (p = 0. 497). In conclusion, no significant association was found between polymorphism of MBL-2 gene and OLP.
AB - TNF-α may be associated with the etiopathogenesis of oral lichen planus (OLP), and it has been suggested that polymorphism of mannose-binding lectin (MBL) increases the in vitro production of TNF- α. The aim of the present study was to assess the relevance of genetic diversity of MBL in OLP. The study sample comprised 90 individuals, 45 OLP patients and 45 healthy volunteers. MBL-2 gene was amplified using real-time PCR. Frequency of A/A genotype was 55. 6% in OLP and 53. 3% in healthy volunteers. Likewise, A/0 heterozygote genotype was found in 42. 2% and 35. 6%; 2. 2% and 11. 1%, had the recessive 0/0 genotype respectively. Frequencies of the "A" and "0" alleles were 77% and 23% in the OLP group and 71. 2% in control group. There were no statistically significant differences regarding genotype frequency (p = 0. 546) or allele frequency (p = 0. 497). In conclusion, no significant association was found between polymorphism of MBL-2 gene and OLP.
KW - Mannose-binding lectin
KW - Oral lichen planus
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=80052652055&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052652055&partnerID=8YFLogxK
U2 - 10.1007/s00784-010-0428-4
DO - 10.1007/s00784-010-0428-4
M3 - Article
C2 - 20499118
AN - SCOPUS:80052652055
VL - 15
SP - 699
EP - 704
JO - Clinical Oral Investigations
JF - Clinical Oral Investigations
SN - 1432-6981
IS - 5
ER -