Mannose binding lectin gene polymorphisms are associated with type 1 diabetes in Brazilian children and adolescents

Jacqueline Araujo; Lucas A C Brandão; Rafael L. Guimarães; Sérgio Santos; Elcy A. Falcão; Michele Milanese; Ludovica Segat; Paulo R. Souza; José Luiz de Lima-Filho; Sergio Crovella

doi:10.1016/j.humimm.2007.05.007

Mannose binding lectin gene polymorphisms are associated with type 1 diabetes in Brazilian children and adolescents

Jacqueline Araujo, Lucas A C Brandão, Rafael L. Guimarães, Sérgio Santos, Elcy A. Falcão, Michele Milanese, Ludovica Segat, Paulo R. Souza, José Luiz de Lima-Filho, Sergio Crovella

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

Mannose-binding lectin is an important constituent of the innate immune system, the serum levels of which are greatly affected by polymorphisms of the MBL2 gene: three polymorphims in exon 1, as well as nucleotide variations in the promoter region of the gene, have been associated with protein deficiency and some infectious and autoimmune disease. The aim of this study was to investigate a possible association between MBL2 gene polymorphisms in patients who have developed type 1 diabetes during childhood and adolescence. We evaluated MBL2 gene polymorphisms in 214 children and adolescents with type 1 diabetes and compared them with a healthy control group, finding significant differences in genotypic and allelic frequencies (p = 0.004 and p = 0.0008, respectively). Our results suggest that patients with type 1 diabetes possessing the 0 allele have a higher risk for developing type 1 diabetes during childhood and adolescence, and that this risk factor is not related to age at diagnosis.

Original language	English
Pages (from-to)	739-743
Number of pages	5
Journal	Human Immunology
Volume	68
Issue number	9
DOIs	https://doi.org/10.1016/j.humimm.2007.05.007
Publication status	Published - Sep 2007

Keywords

MBL2
Melting temperature assay
Polymorphisms
Type 1 diabetes

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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Mannose binding lectin gene polymorphisms are associated with type 1 diabetes in Brazilian children and adolescents. / Araujo, Jacqueline; Brandão, Lucas A C; Guimarães, Rafael L.; Santos, Sérgio; Falcão, Elcy A.; Milanese, Michele; Segat, Ludovica; Souza, Paulo R.; de Lima-Filho, José Luiz; Crovella, Sergio.

In: Human Immunology, Vol. 68, No. 9, 09.2007, p. 739-743.

Research output: Contribution to journal › Article › peer-review

Araujo, Jacqueline ; Brandão, Lucas A C ; Guimarães, Rafael L. ; Santos, Sérgio ; Falcão, Elcy A. ; Milanese, Michele ; Segat, Ludovica ; Souza, Paulo R. ; de Lima-Filho, José Luiz ; Crovella, Sergio. / Mannose binding lectin gene polymorphisms are associated with type 1 diabetes in Brazilian children and adolescents. In: Human Immunology. 2007 ; Vol. 68, No. 9. pp. 739-743.

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abstract = "Mannose-binding lectin is an important constituent of the innate immune system, the serum levels of which are greatly affected by polymorphisms of the MBL2 gene: three polymorphims in exon 1, as well as nucleotide variations in the promoter region of the gene, have been associated with protein deficiency and some infectious and autoimmune disease. The aim of this study was to investigate a possible association between MBL2 gene polymorphisms in patients who have developed type 1 diabetes during childhood and adolescence. We evaluated MBL2 gene polymorphisms in 214 children and adolescents with type 1 diabetes and compared them with a healthy control group, finding significant differences in genotypic and allelic frequencies (p = 0.004 and p = 0.0008, respectively). Our results suggest that patients with type 1 diabetes possessing the 0 allele have a higher risk for developing type 1 diabetes during childhood and adolescence, and that this risk factor is not related to age at diagnosis.",

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