Abstract
Factors related to bacterial virulence and/or to the host have been implicated in the pathogenesis of recurrent urinary tract infections (rUTI), but in most cases the cause is unknown. Mannose binding lectin (MBL) is an acute phase glycoprotein that exerts immunological functions by binding to the surface of a variety of pathogens. Some human gene variants reduce MBL activity thereby predisposing the host to bacterial and viral infections. The aim of this study was to investigate MBL2 gene variants in relation to rUTI risk. Six MBL gene variants and seven haplotypes were analyzed by PCR and direct sequencing in rUTI patients (n = 83) and in healthy subjects from southern Italy (n = 642). The frequencies of the L allele (-550) and the HYPA haplotype were higher in controls than in patients stratified according to sex (p <0.05). Our data indicate that the HYPA haplotype in the MBL2 gene could be associated with a minor risk of developing rUTI in males.
| Original language | English |
|---|---|
| Pages (from-to) | 100-102 |
| Number of pages | 3 |
| Journal | International Journal of Infectious Diseases |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2014 |
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Keywords
- Haplotype
- MBL
- Molecular analysis
- RUTI
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
- Medicine(all)
Cite this
Mannose-binding lectin genetic analysis : Possible protective role of the HYPA haplotype in the development of recurrent urinary tract infections in men. / Scudiero, Olga; Monaco, Maria Ludovica; Nigro, Ersilia; Capasso, Mario; Guida, Maurizio; Sardo, Attilio Di Spiezio; Prezioso, Domenico; Daniele, Aurora; Castaldo, Giuseppe.
In: International Journal of Infectious Diseases, Vol. 19, No. 1, 02.2014, p. 100-102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mannose-binding lectin genetic analysis
T2 - Possible protective role of the HYPA haplotype in the development of recurrent urinary tract infections in men
AU - Scudiero, Olga
AU - Monaco, Maria Ludovica
AU - Nigro, Ersilia
AU - Capasso, Mario
AU - Guida, Maurizio
AU - Sardo, Attilio Di Spiezio
AU - Prezioso, Domenico
AU - Daniele, Aurora
AU - Castaldo, Giuseppe
PY - 2014/2
Y1 - 2014/2
N2 - Factors related to bacterial virulence and/or to the host have been implicated in the pathogenesis of recurrent urinary tract infections (rUTI), but in most cases the cause is unknown. Mannose binding lectin (MBL) is an acute phase glycoprotein that exerts immunological functions by binding to the surface of a variety of pathogens. Some human gene variants reduce MBL activity thereby predisposing the host to bacterial and viral infections. The aim of this study was to investigate MBL2 gene variants in relation to rUTI risk. Six MBL gene variants and seven haplotypes were analyzed by PCR and direct sequencing in rUTI patients (n = 83) and in healthy subjects from southern Italy (n = 642). The frequencies of the L allele (-550) and the HYPA haplotype were higher in controls than in patients stratified according to sex (p <0.05). Our data indicate that the HYPA haplotype in the MBL2 gene could be associated with a minor risk of developing rUTI in males.
AB - Factors related to bacterial virulence and/or to the host have been implicated in the pathogenesis of recurrent urinary tract infections (rUTI), but in most cases the cause is unknown. Mannose binding lectin (MBL) is an acute phase glycoprotein that exerts immunological functions by binding to the surface of a variety of pathogens. Some human gene variants reduce MBL activity thereby predisposing the host to bacterial and viral infections. The aim of this study was to investigate MBL2 gene variants in relation to rUTI risk. Six MBL gene variants and seven haplotypes were analyzed by PCR and direct sequencing in rUTI patients (n = 83) and in healthy subjects from southern Italy (n = 642). The frequencies of the L allele (-550) and the HYPA haplotype were higher in controls than in patients stratified according to sex (p <0.05). Our data indicate that the HYPA haplotype in the MBL2 gene could be associated with a minor risk of developing rUTI in males.
KW - Haplotype
KW - MBL
KW - Molecular analysis
KW - RUTI
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UR - http://www.scopus.com/inward/citedby.url?scp=84892846443&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2013.10.019
DO - 10.1016/j.ijid.2013.10.019
M3 - Article
VL - 19
SP - 100
EP - 102
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
IS - 1
ER -