Mannose-binding lectin genetic analysis: Possible protective role of the HYPA haplotype in the development of recurrent urinary tract infections in men

Olga Scudiero, Maria Ludovica Monaco, Ersilia Nigro, Mario Capasso, Maurizio Guida, Attilio Di Spiezio Sardo, Domenico Prezioso, Aurora Daniele, Giuseppe Castaldo

Research output: Contribution to journalArticle

Abstract

Factors related to bacterial virulence and/or to the host have been implicated in the pathogenesis of recurrent urinary tract infections (rUTI), but in most cases the cause is unknown. Mannose binding lectin (MBL) is an acute phase glycoprotein that exerts immunological functions by binding to the surface of a variety of pathogens. Some human gene variants reduce MBL activity thereby predisposing the host to bacterial and viral infections. The aim of this study was to investigate MBL2 gene variants in relation to rUTI risk. Six MBL gene variants and seven haplotypes were analyzed by PCR and direct sequencing in rUTI patients (n = 83) and in healthy subjects from southern Italy (n = 642). The frequencies of the L allele (-550) and the HYPA haplotype were higher in controls than in patients stratified according to sex (p <0.05). Our data indicate that the HYPA haplotype in the MBL2 gene could be associated with a minor risk of developing rUTI in males.

Original languageEnglish
Pages (from-to)100-102
Number of pages3
JournalInternational Journal of Infectious Diseases
Volume19
Issue number1
DOIs
Publication statusPublished - Feb 2014

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Keywords

  • Haplotype
  • MBL
  • Molecular analysis
  • RUTI

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

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