Mannose Binding Lectin, S100 B Protein, and Brain Injuries in Neonates With Perinatal Asphyxia

Cinzia Auriti, Giusi Prencipe, Rita Inglese, Maria Moriondo, Francesco Nieddu, Vito Mondı̀, Daniela Longo, Silvia Bucci, Tamara Del Pinto, Laura Timelli, Vincenzo Maria Di Ciommo

Research output: Contribution to journalArticlepeer-review

Abstract

Perinatal asphyxia triggers an acute inflammatory response in the injured brain. Complement activation and neuroinflammation worsen brain damage after a systemic ischemia/reperfusion insult. The increase of mannose binding lectin (MBL) during asphyxia may contribute to the brain damage, via activation of the complement lectin pathway. The possible role of MBL2 gene variants in influencing the severity of post-asphyxia brain injuries is still unexplored. This retrospective study included 53 asphyxiated neonates: 42 underwent therapeutic hypothermia (TH) and 11 did not because they were admitted to the NICU later than 6 h after the hypoxic insult. Blood samples from TH-treated and untreated patients were genotyped for MBL2 gene variants, and biomarker plasma levels (MBL and S100 B protein) were measured at different time points: during hypothermia, during rewarming, and at 7–10 days of life. The timing of blood sampling, except for the T1 sample, was the same in untreated infants. Highest (peak) levels of MBL and MBL2 genotypes were correlated to neuroimaging brain damage or death and long-term neurodevelopmental delay. MBL2 wild-type genotype was associated with the highest MBL levels and worst brain damage on MRI (p = 0.046) at 7–10 days after hypoxia. MBL increased in both groups and S100B decreased, slightly more in treated than in untreated neonates. The progressive increase of MBL (p = 0.08) and to be untreated with TH (p = 0.08) increased the risk of brain damage or death at 7–10 days of life, without affecting neurodevelopmental outcomes at 1 year. The effect of TH on MBL plasma profiles is uncertain.

Original languageEnglish
Article number527
JournalFrontiers in Pediatrics
Volume8
DOIs
Publication statusPublished - Sep 17 2020

Keywords

  • genotype
  • mannose binding lectin
  • perinatal asphyxia
  • S100B protein
  • therapeutic hypothermia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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